给战友点希望－－硝唑尼特治疗慢肝

山东小兵

原帖由 赤子之心 于 2010-3-30 16:14 发表
用了一天的时间看完这个帖子。
感动，感谢所有一直在努力救人救己的人，名单不一一列出。
也伤感，乙人像是被世界、被上帝抛弃的一群，只能自己钻研、试验。
我不怕死，我也申请加入试验。
只是不知道怎么买，希望小兵给个qq号，指 ...

关于qq号，这个抱歉，实在是不胜压力
至于买硝，点我的签名档，那里有网址，我也就只能提供这些了；

齐欢畅2

我自己做的购买指导，希望有用，想买小错尼特的点这里https://www.buy-pharma.com/Gener ... _Tablets-p-867.html

[ 本帖最后由 齐欢畅2 于 2010-3-30 19:10 编辑 ]

freshnail

11号宅男

原帖由 lemonades 于 2010-3-30 00:02 发表
至于未发作的，可以等三个药：
1.tdf＋恩曲他滨组合   目前在IV期临床，有个例表示效果特别好。是治疗HIV的，现在北美市场上有卖。
2.硝唑尼特的II代缓释制剂   目前在HCV试验中显示出优于硝唑尼特的作用。
3.Replicor   

1，市场上有卖，2硝唑尼特有卖。上市会比较快点，1最快要2年，2需要至少三年。3就要更慢点，生物制剂，大规模生产也许存在问题。

谢谢柠檬带来的消息。

唉，想想要是再年轻十岁该多好啊，会静静地等待着这些药物的出现。

可惜，国内残忍的生存环境和大众对HBV落后的认识，已经快将我的信心、激情和人生耗干了...

怕脂肪肝

加油。。。。。。

lemonades

治疗禽流感的机制     也许可以给些提示。
Thiazolides, a new class of anti-influenza molecules targeting viral hemagglutinin at the post-translational level.
Rossignol JF, La Frazia S, Chiappa L, Ciucci A, Santoro MG.

Department of Medicine, Stanford University School of Medicine, Stanford, California 94305-5187, USA.

The emergence of highly contagious influenza A virus strains, such as the new H1N1 swine influenza, represents a serious threat to global human health. Efforts to control emerging influenza strains focus on surveillance and early diagnosis, as well as development of effective vaccines and novel antiviral drugs. Herein we document the anti-influenza activity of the anti-infective drug nitazoxanide and its active circulating-metabolite tizoxanide and describe a class of second generation thiazolides effective against influenza A virus. Thiazolides inhibit the replication of H1N1 and different other strains of influenza A virus by a novel mechanism: they act at post-translational level by selectively blocking the maturation of the viral hemagglutinin at a stage preceding resistance to endoglycosidase H digestion, thus impairing hemagglutinin intracellular trafficking and insertion into the host plasma membrane, a key step for correct assembly and exit of the virus from the host cell. Targeting the maturation of the viral glycoprotein offers the opportunity to disrupt the production of infectious viral particles attacking the pathogen at a level different from the currently available anti-influenza drugs. The results indicate that thiazolides may represent a new class of antiviral drugs effective against influenza A infection.

[ 本帖最后由 lemonades 于 2010-3-31 12:02 编辑 ]

lemonades

希望能有战友帮忙找到这篇文章的原文，这篇很重要。谢谢！
LC: analysis of photodegradation kinetics of nitazoxanide in pharmaceutical formulations.
Malesuik MD, Gonçalves HM, Paim CS, Schapoval EE, Steppe M.

Universidade Federal do Rio Grande do Sul, Faculdade de Farmácia, Programa de Pós-Graduação em Ciências Farmacêuticas, Porto Alegre, Rio Grande do Sul, Brazil. [email protected]

Nitazoxanide is a new broad-spectrum, antiparasitic drug agent. The photodegradation of nitazoxanide was studied in order to investigate the degradation kinetics of this drug. The analyses of the degraded samples were performed by a stability-indicating liquid chromatographic method. The degradation was carried out in acetonitrile with coated tablets or oral suspension powder in quartz cells under UVC light at 254 nm. The kinetics parameters, such as order of reaction, rate constants, half-life (t(1/2)), and the time when 90% of the drug original concentration was left, were determined. The photodegradation of nitazoxanide for both pharmaceutical formulations in acetonitrile solution shows a zero-order kinetics under the applied experimental conditions. The obtained results confirm the reliability of the chromatographic method for determining the kinetics run of nitazoxanide in the presence of its degradation products. The present study reveals the photolability of the drug in solution. Thus, appropriated photoprotection is recommended during the manipulation of the drug.

[ 本帖最后由 lemonades 于 2010-3-31 11:50 编辑 ]

lemonades

节选自：
Targeting host factors: A novel rationale for the management of hepatitis C virus

Nitazoxanide
Nitazoxanide is an oral prodrug of a thiazolide (tizoxanide), and was approved for the treatment of protozoal infections[93]. In addition to having antiprotozoal and antibacterial activity, nitazoxanide coincidently was discovered to inhibit HCV replication[94] through a recently identified host-mediated mechanism of action. The antiviral mechanism of action of nitazoxanide appears to be different from the mechanism of action of nitazoxanide in protozoa and anaerobic bacteria. Recent studies suggest that nitazoxanide and other thiazolides selectively induce PKR phosphorylation, which leads to increased cell concentration of phosphorylated eIF2, a naturally occurring antiviral intracellular protein (Figure ​(Figure33)[95]. This mechanism of action is only triggered when a cell is infected with HCV while nitazoxanide has no effect in uninfected cells, which provides a possible explanation for its very low rate of toxicity.

Furthermore, nitazoxanide does not appear to induce antiviral resistance, based on an attempt to produce a resistance to nitazoxanide and tizoxanide in HCV replicon-containing cell lines[96]. With serial exposure to nitazoxanide or tizoxanide, direct HCV viral resistance did not emerge, suggesting that the genetic barrier to the development of resistance to nitazoxanide is high. The drug has been recently studied in combination with the standard of care in 96 treatment-naive patients in Egypt infected with genotype 4 HCV infection. The combination of nitazoxanide, peginterferon α-2a, and ribavirin increased the percentage of patients with rapid and sustained virologic responses, compared with patients given peginterferon plus ribavirin, without an increase in adverse events[97].

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jndkbdzl

lemonades，让我们一起加油。