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回复 bigben446 的帖子
【我不清楚有没有那种乙肝高复制的肝癌患者，如果有文献报道，请告诉我】A population-based cohort study for the risk factors of HCC among hepatitis B virus mono-infected subjects in Japan.
http://www.ncbi.nlm.nih.gov/pubmed?term=Journal%20of%20Gastroenterology%202011%20%2046%20117%E2%80%93124
Abstract
BACKGROUND:
There have only been a few prospective studies investigating risk factors associated with the development of hepatocellular carcinoma (HCC) among chronic hepatitis B patients all over the world, and no study has been conducted in Japanese population.
METHODS:
A population-based cohort consisting of 19393 subjects (middle aged or older) with over 13 years' follow-up was investigated in Japan.
RESULTS:
Of 19393 subjects, 479 had hepatitis B virus (HBV) mono-infection (2.5%). During the 245923 person-years' follow-up (average follow-up period 12.7 years), 13 cases of newly diagnosed HCC were documented in the HBV mono-infected group. Several factors at baseline (male, smoking, alanine aminotransferase, the positivity of HBe antigen and HB core-related antigen, the proportion of HBV DNA ≥ 5 log copies/mL, T1753V mutation, and A1762T/G1764A double mutation) were significantly associated with HCC among HBV mono-infected subjects. Multivariate-adjusted Cox hazard model showed that A1762T/G1764A (hazard ratio 7.05 [95% confidence interval (CI) 1.03-48.12, P = 0.046]) was the only independent risk factor for the development of HCC. Kaplan-Meier method also showed that the probability of HCC occurrence-free was significantly lower in HBV mono-infected subjects with A1762T/G1764A double mutation than those without these mutations.
CONCLUSION:
HBV mono-infected subjects with A1762T/G1764A double mutation could be at high risk of HCC development during the natural course of HBV infection.
肝癌・非肝癌分组 HBV感染者的特点[td]
| 肝癌组
| 非肝癌组 | P値 | ± 是標準偏差、( %)は各分组中比例，NS表示没有统计学意义 | 人数 | 13 |
| 466
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| 年齢 | 58.8 | ± 6.3 | 55.1 | ± 8.5 | NS | 男性 | 11 | (85%) | 209 | (45%) | <0.005 | BMI | 22.3 | ± 2.9 | 23.4 | ± 3.0 | NS | 酒精摂取 | 0 |
| 36
| (8%) | NS | 喫煙 | 7 | (54%) | 92 | (20%) | <0.005 | ALT (IU/L) | 44.7 | ± 30.0 | 23.8 | ± 20.4 | <0.001 | γ-GTP (IU/L) | 31.7 | ± 16.2 | 23.2 | ± 25.2 | NS | HBeAg 陽性 | 3 | (23%) | 14 | (3%) | <0.001 | HBcrAg (kU/mL) | 39276 | ± 121639 | 6486 | ± 47987 | <0.05 | HBcrAg 陽性 | 7 | (54%) | 99 | (21%) | <0.005 | HBV DNA (log copies/mL) | 6.1 |
| 4.1
|
| <0.001
| HBV DNA ≧ 5 log copies/mL | 6 | (46%) | 39 | (8%) | <0.001 | 遺伝子型 B1/Bj | 4 | (31%) | 264 | (57%) | NS (0.0637) | 遺伝子型 C2/Ce | 9 | (69%) | 202 | (43%) | NS (0.0637) | C1653T変異 | 6 | (46%) | 116/421 | (28%) | NS | T1753 V変異 | 6 | (46%) | 78/421 | (19%) | <0.05 | A1762T/G1764A二重変異 | 11 | (87%) | 142/421 | (34%) | <0.001 | G1896A変異 | 11 | (87%) | 348/421 | (83%) | NS |
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楼主: 齐欢畅2
发表于 2016-4-26 22:43
