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interdetect

回复 StephenW 的帖子

兄台，你视力也不好啊？
2004年8月17日是2003年以后吗？
即使拉米有1%，那也比你恩替卡韦1.3%小很多吧？

对不起了

回复 心路2009 的帖子

多谢斑竹，七骗八骗搞来不少分，上升到师长级别了，不枉我昨晚辛苦上网到半夜。

interdetect

回复 StephenW 的帖子


一句话总结：

1. 美国FDA判定恩替卡韦属于“致癌性化合物”！         可靠
2. 美国FDA有没有判定拉米夫定属于“致癌性化合物”？   没

咱不是彻底否定恩替，咱的目的是说“任何东西都有两面性”，你不能只看到他好的一面，也不好只看到他差的一面。有句话说的好“存在即是合理的！”拉米也好，恩替也好，在市场上使用就说明有他本身的价值！

“承认缺点，发挥优点”或者说“扬长避短”，但不能“扬长忌短”！

对不起了

回复 interdetect 的帖子

恩替的潜在致癌性连骆老都很担心，在他门诊病人里面已经有发现，所以骆老建议服用恩替不要超过4年，他推介小三阳的治疗方案就是：恩替2年--3年，拉米加阿德3年--4年后用阿德维持。

StephenW

interdetect 发表于 2011-4-6 13:18
回复 StephenW 的帖子

"再问: 自2005年以来,美国FDA有没有发出任何警告?

StephenW

再问: 自2005年以来,美国FDA有没有发出任何警告?

我回答您的问题, 请回答我的问题.

interdetect

啥也不说了，看看恩替卡韦在动物上诱发的肿瘤吧。
Long-term oral carcinogenicity studies of entecavir in mice and rats were carried out . In mouse and rat studies, entecavir was positive for carcinogenic findings.

In mice, lung adenomas were increased in males and females. Lung carcinomas in both male and female mice were increased. Combined lung adenomas and carcinomas were increased in male mice and in female mice. Tumor development was preceded by pneumocyte proliferation in the lung, which was not observed in rats, dogs, or monkeys administered entecavir, supporting the conclusion that lung tumors in mice may be a species-specific event. Hepatocellular carcinomas were increased in males and combined liver adenomas and carcinomas were also increased. Vascular tumors in female mice (hemangiomas of ovaries and uterus and hemangiosarcomas of spleen) were increased. In rats, hepatocellular adenomas were increased in females; combined adenomas and carcinomas were also increased in females. Brain gliomas were induced in both males and females. Skin fibromas were induced in females.

是不是警钟长鸣呢？？？

StephenW

interdetect 发表于 2011-4-6 14:04
啥也不说了，看看恩替卡韦在动物上诱发的肿瘤吧。
Long-term oral carcinogenicity studies of entecavir i ...

Yes, a clear warning. Warning leads to investigation. So I ask you again, did the investigation raise any further warning?

interdetect

回复 StephenW 的帖子

你还没完了？我给你找出一个来，你又来一个？然后再问还有没有？
老外是这么做事情的啊？无理取闹。
你既然承认了是一个警告了，那就ok了。