Vitamins B status and antioxidative defense in patients with chronic hepatitis B

StephenW

Comment from a reader(her personal opinion only) on the HepB-list.
"Really worth paying attention to this.  And probably supplementing with Vit B
complex if nutrition is "less than perfect" (as it is for most of us).  ciao"
一个读者的评论（她个人的意见只）:
“真正值得重视的。并可能与补充维生素Bcomplex
如果营养是“不完美”（我们大多数人的）。ciao“


<http://www.springerlink.com/content/y762g54l761q9w81/>

Chemistry and Materials Science European Journal of Nutrition
DOI: 10.1007/s00394-010-0156-1Online First™
Original Contribution

Vitamins B status and antioxidative defense in patients with chronic hepatitis B
or hepatitis C virus infection

Chun-che Lin, Wen-hu Liu, Zhi-hong Wang and Mei-chin Yin

Abstract

Background & Aims  
The impact of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection upon
B vitamins status and antioxidative defense in infected patients was examined.

Methods  
Dietary record and blood levels of B vitamins and oxidative stress–associated
biomarkers were determined for 195 healthy controls, 132 HBV, and 114 HCV
patients.

Results  
HBV-infected patients had significantly higher levels of total cholesterol, free
fatty acids (FFA), and lower ghrelin level (p < 0.05); and HCV-infected patients
had significantly higher Ishak inflammation score and lactate dehydrogenase
activity (p < 0.05). HBV patients had significantly lower red blood cell (RBC)
vitamins B2 and B6 levels, and HCV infection significantly decreased vitamins
B2, B6 and folate levels in RBC and/or plasma (p < 0.05). Correlation
coefficients of RBC vitamin B2 versus serum FFA in HBV patients, RBC vitamins B2
and B6 versus HCV RNA and Ishak inflammation score, and plasma vitamin B6 vs
Ishak inflammation score in HCV patients were <−0.5. HBV-infected patients had
significantly higher oxidized glutathione level and lower glutathione peroxidase
activity (p < 0.05), but HCV patients had significantly lower superoxide
dismutase and catalase activities (p < 0.05).

Conclusion  
HBV or HCV infection enhanced oxidative stress and lowered B vitamins in
circulation. In order to avoid other healthy risk, nutrition status should be
monitored and limitation or supplementation of certain nutrients might be
helpful for HBV- or HCV-infected patients

<http://www.springerlink.com/content/y762g54l761q9w81/>

化学与材料科学营养欧洲杂志
分类号：10.1007/s00394-010-0156-1Online第一™
原创性贡献

维生素B的状态和抗氧化防御患者慢性乙型肝炎
或丙型肝炎病毒感染

林俊哲，文胡柳，王志红，梅津贤

摘要

背景和目的
B型肝炎病毒（HBV）或丙型肝炎病毒（HCV）感染后的影响
B族维生素中的地位和抗氧化防御感染的患者进行了检查。

方法
膳食记录和血液中的B族维生素和氧化应激相关
生物标志物被确定为195名健康对照组，132乙肝病毒，丙肝病毒和114
病人。

结果
HBV感染患者血清总胆固醇水平显着提高，免费
脂肪酸（FFA），并降低生长素水平（P“0.05）和丙型肝炎病毒感染的病人
有较高的伊沙克炎症评分和乳酸脱氢酶
活性（P“0.05）。乙肝患者有显着降低红血细胞（红细胞）
维生素B2和B6的水平，并显着降低维生素C型肝炎病毒感染
B2，B6和红细胞叶酸水平和/或血浆性（P“0.05）。相关
红细胞与血清游离脂肪酸维生素B2的系数乙肝患者中，红细胞维生素B2
和B6与丙型肝炎病毒RNA和Ishak炎症评分，并与血浆维生素B6
伊沙克在丙型肝炎患者炎症评分均<-0.5。乙肝病毒感染的患者
氧化型谷胱甘肽的水平显着提高，降低谷胱甘肽过氧化酶
活性（P“0.05），但C型肝炎患者有显着降低超氧
氧化物歧化酶和过氧化氢酶活性（P“0.05）。

结论
HBV或HCV感染和降低氧化应激增强B族维生素在
流通。为了避免其他健康风险，营养状况，应
监视和限制或补充某些营养素可能
有助于乙肝病毒或丙型肝炎病毒感染的病人




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