标题: Vitamins B status and antioxidative defense in patients with chronic hepatitis B [打印本页] 作者: StephenW 时间: 2011-1-8 13:10 标题: Vitamins B status and antioxidative defense in patients with chronic hepatitis B
本帖最后由 风雨不动 于 2012-4-14 15:43 编辑
Comment from a reader(her personal opinion only) on the HepB-list.
"Really worth paying attention to this. And probably supplementing with Vit B
complex if nutrition is "less than perfect" (as it is for most of us). ciao"
一个读者的评论(她个人的意见只):
“真正值得重视的。并可能与补充维生素Bcomplex
如果营养是“不完美”(我们大多数人的)。ciao“
Chemistry and Materials Science European Journal of Nutrition
DOI: 10.1007/s00394-010-0156-1Online First™
Original Contribution
Vitamins B status and antioxidative defense in patients with chronic hepatitis B
or hepatitis C virus infection
Chun-che Lin, Wen-hu Liu, Zhi-hong Wang and Mei-chin Yin
Abstract
Background & Aims
The impact of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection upon
B vitamins status and antioxidative defense in infected patients was examined.
Methods
Dietary record and blood levels of B vitamins and oxidative stress–associated
biomarkers were determined for 195 healthy controls, 132 HBV, and 114 HCV
patients.
Results
HBV-infected patients had significantly higher levels of total cholesterol, free
fatty acids (FFA), and lower ghrelin level (p < 0.05); and HCV-infected patients
had significantly higher Ishak inflammation score and lactate dehydrogenase
activity (p < 0.05). HBV patients had significantly lower red blood cell (RBC)
vitamins B2 and B6 levels, and HCV infection significantly decreased vitamins
B2, B6 and folate levels in RBC and/or plasma (p < 0.05). Correlation
coefficients of RBC vitamin B2 versus serum FFA in HBV patients, RBC vitamins B2
and B6 versus HCV RNA and Ishak inflammation score, and plasma vitamin B6 vs
Ishak inflammation score in HCV patients were <−0.5. HBV-infected patients had
significantly higher oxidized glutathione level and lower glutathione peroxidase
activity (p < 0.05), but HCV patients had significantly lower superoxide
dismutase and catalase activities (p < 0.05).
Conclusion
HBV or HCV infection enhanced oxidative stress and lowered B vitamins in
circulation. In order to avoid other healthy risk, nutrition status should be
monitored and limitation or supplementation of certain nutrients might be
helpful for HBV- or HCV-infected patients