请问HLA-A2代表什么？

gelabang

请问HLA-A2代表什么？我是阳性，貌似阳性的都不好吧，有什么危害？？



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虎豆

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StephenW

回复 gelabang 的帖子

I am not a expert, so what I say may be wrong.我不是专家，所以我说可能是错误的.
Your question covers a big area in immunology, so it is not possible to say whether your HLA-A2 status is good or bad.你的问题覆盖了在免疫学中很大面积，因此无法说您的HLA - A2的状态是好还是坏.
The following abstract discusses relationship between HLA-A2 and Lamivudine treatment outcome.下面的论文讨论HLA- A2和拉米夫定治疗效果的关系。
Hope this will help you.希望这会帮助你。

http://www.globulins.org/showabstract.php?pmid=19096254
Clinical outcomes of lamivudine therapy and HLA alleles in chronic hepatitis B patients
JM Oh, KH Kwon, JE Kim, JH Choi, SH Beom, SH Lee, YJ Lee, MY Park, MK Jung, KH Lee

[size=1.3em]BACKGROUND/AIMS: The human leukocyte  antigen (HLA) system is an integral component of immune response.Highly polymorphic HLA genes may play a pivotal role in the response of antiviral therapy. We investigated the effects of HLA gene polymorphism on the clinical outcome of chronic hepatitis B patients who received lamivudine treatment. METHODS: Depending on their clinical response to lamivudine therapy, a total of sixty one patients were divided into following groups; non-responders, viral breakthroughers, relapsers, and seroconverters. HLA-A, -B, -Cw, -DRB and HLA-DRB1 alleles typing was performed on each group through the polymerase chain reaction and the sequence-specific oligonucleotide hybridization method. The distribution patterns of HLA-A, HLA-B, HLA-Cw, HLA-DRB, and HLA-DRB1were then analysed. RESULTS: When non-responders were compared to the other groups, high frequencies in HLA-Cw1, HLA-DRB14 and HLA-DRB4(p=0.015, 0.033 and 0.004 respectively) were evident. When seroconverters were compared to viral breakthroughers, high frequencies in HLA-A2 and HLA-DRB4 (p=0.048, 0.025 respectively) were evident.CONCLUSIONS: Our data suggests that HLA-A2, HLA-Cw1, HLA-DRB14 genes are related to the clinical outcomes of lamivudine treatment in chronic hepatitis B patients. These genes may be used in the prediction of the clinical outcome of lamivudine therapy in chronic hepatitis B patients.
[拉米夫定治疗的临床结果和HLA等位基因在慢性乙型肝炎患者]


JM Oh, KH Kwon, JE Kim, JH Choi, SH Beom, SH Lee, YJ Lee, MY Park, MK Jung, KH Lee

背景/目的：人类白细胞抗原（HLA）系统是一种免疫反应的一个组成部分。 HLA基因具有高度多态性可能在抗病毒治疗反应举足轻重的作用。我们调查对慢性乙型肝炎患者拉米夫定治疗的临床谁收到的HLA基因多态性结果的影响。方法：根据他们的临床反应而定，拉米夫定治疗，一共有六十名患者被分为以下组;非应答，病毒breakthroughers，relapsers和seroconverters。与HLA - A，- B的，- Cw的，- DRB和HLA - DRB1基因分型各组进行，通过聚合酶链反应和序列特异性寡核苷酸杂交法。人类白细胞抗原-阿和HLA- B的和HLA- Cw的，人类白细胞抗原- DRB的，和HLA - DRB1基因的分布格局进行分析。结果：当非反应进行了比较，其他各组，在HLA- Cw1高频率和HLA- DRB14和HLA - DRB4（p值=0.015，0.033和0.004分别）是显而易见的。当seroconverters breakthroughers病毒进行了比较，在HLA- A2号和HLA - DRB4高频率（p值=0.048，0.025分别）是显而易见的。结论：我们的数据表明，与HLA - A2和HLA- Cw1和HLA- DRB14基因与拉米夫定治疗慢性乙型肝炎患者的临床结果。这些基因可能被用于对拉米夫定治疗慢性乙型肝炎患者的临床结果的预测。