I am not a expert, so what I say may be wrong.我不是专家,所以我说可能是错误的.
Your question covers a big area in immunology, so it is not possible to say whether your HLA-A2 status is good or bad.你的问题覆盖了在免疫学中很大面积,因此无法说您的HLA - A2的状态是好还是坏.
The following abstract discusses relationship between HLA-A2 and Lamivudine treatment outcome.下面的论文讨论HLA- A2和拉米夫定治疗效果的关系。
Hope this will help you.希望这会帮助你。
[size=1.3em]BACKGROUND/AIMS: The human leukocyte antigen (HLA) system is an integral component of immune response.Highly polymorphic HLA genes may play a pivotal role in the response of antiviral therapy. We investigated the effects of HLA gene polymorphism on the clinical outcome of chronic hepatitis B patients who received lamivudine treatment. METHODS: Depending on their clinical response to lamivudine therapy, a total of sixty one patients were divided into following groups; non-responders, viral breakthroughers, relapsers, and seroconverters. HLA-A, -B, -Cw, -DRB and HLA-DRB1 alleles typing was performed on each group through the polymerase chain reaction and the sequence-specific oligonucleotide hybridization method. The distribution patterns of HLA-A, HLA-B, HLA-Cw, HLA-DRB, and HLA-DRB1were then analysed. RESULTS: When non-responders were compared to the other groups, high frequencies in HLA-Cw1, HLA-DRB14 and HLA-DRB4(p=0.015, 0.033 and 0.004 respectively) were evident. When seroconverters were compared to viral breakthroughers, high frequencies in HLA-A2 and HLA-DRB4 (p=0.048, 0.025 respectively) were evident.CONCLUSIONS: Our data suggests that HLA-A2, HLA-Cw1, HLA-DRB14 genes are related to the clinical outcomes of lamivudine treatment in chronic hepatitis B patients. These genes may be used in the prediction of the clinical outcome of lamivudine therapy in chronic hepatitis B patients.
[拉米夫定治疗的临床结果和HLA等位基因在慢性乙型肝炎患者]
JM Oh, KH Kwon, JE Kim, JH Choi, SH Beom, SH Lee, YJ Lee, MY Park, MK Jung, KH Lee