serum clusterin as a surveillance tool for hepatocellular carcinoma

StephenW

<http://www3.interscience.wiley.com/journal/123207055/abstract>

Journal of Gastroenterology and Hepatology
Volume 25 Issue 6, Pages 1123 - 1128
Published Online: 7 Dec 2009
Journal compilation © 2010 Blackwell Publishing Asia Pty Ltd and Journal of
Gastroenterology and Hepatology Foundation


HEPATOLOGY
Evaluation of serum clusterin as a surveillance tool for human hepatocellular
carcinoma with hepatitis B virus related cirrhosis

Yi Wang,* Yan-Hui Liu, † Shi-Juan Mai,* Long-Jun He,* Yi-Ji Liao,* Hai-Xia
Deng,* Xin-Yuan Guan,* Yi-Xin Zeng,* Hsiang-Fu Kung* and Dan Xie*

  *State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen
University, Guangzhou, Guangdong, China, and  â€  Department of Pathology and
Laboratory Medicine, Guangdong Provincial People's Hospital, Guangzhou,
Guangdong, China

Correspondence to  Professor Dan Xie, State Key Laboratory of Oncology in
South China, Cancer Center, Sun Yat-Sen University, no. 651, Dongfeng Road
East, Guangzhou, 510060, China. Email: [email protected]

Copyright Journal compilation © 2010 Blackwell Publishing Asia Pty Ltd and
Journal of Gastroenterology and Hepatology Foundation

ABSTRACT
Background and Aim: Hepatocellular carcinoma (HCC) is a common human cancer
worldwide. The levels of serum clusterin in HCC patients and its potential
diagnostic significance is not clear. We aimed to evaluate the clinical use of
serum clusterin levels as a surveillance tool for HCC with hepatitis B virus
(HBV) related cirrhosis.
Methods: Twenty-two cases of healthy subjects, 31 cases of HBV carriers, 26
patients with chronic hepatitis B, 29 patients with cirrhosis, and 76 patients
with HCC were enrolled in this study. Serum levels of clusterin were measured
by a sandwich enzyme-linked immunosorbent assay.
Results: The serum clusterin levels in HCC patients were significantly lower
than that in healthy, HBV carriers and chronic hepatitis B, but statistically
higher than in cirrhosis patients. Receiver operator characteristic (ROC)
curve indicated that a serum clusterin value of 50 µg/mL yielded the best
sensitivity (91%) and specificity (83%) for differentiating HCC patients with
HBV-related cirrhosis from those with HBV-related cirrhosis. The optimal alpha
fetoprotein (AFP) cutoff value was 15 ng/mL and was inferior to the clusterin
value of 50 µg/mL, the area under the ROC curves being 0.937 versus 0.781,
respectively (P < 0.05).
Conclusions: Serum clusterin was more sensitive and specific than serum AFP
for differentiating HCC patients with HBV-related cirrhosis from those with
HBV-related liver cirrhosis, and may be a useful surveillance tool of HCC
based on HBV-related cirrhosis.

-------------------------------------------------------------------------------
-
Accepted for publication 16 November 2009.
DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1440-1746.2009.06205



(6.合.彩).足球.篮球...各类投注开户下注

第一投注.现金网:招代理年薪10万以上:6668.cc