标题: serum clusterin as a surveillance tool for hepatocellular carcinoma [打印本页] 作者: StephenW 时间: 2010-5-28 20:17 标题: serum clusterin as a surveillance tool for hepatocellular carcinoma
HEPATOLOGY
Evaluation of serum clusterin as a surveillance tool for human hepatocellular
carcinoma with hepatitis B virus related cirrhosis
Yi Wang,* Yan-Hui Liu, †Shi-Juan Mai,* Long-Jun He,* Yi-Ji Liao,* Hai-Xia
Deng,* Xin-Yuan Guan,* Yi-Xin Zeng,* Hsiang-Fu Kung* and Dan Xie*
*State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen
University, Guangzhou, Guangdong, China, and †Department of Pathology and
Laboratory Medicine, Guangdong Provincial People's Hospital, Guangzhou,
Guangdong, China
Correspondence to Professor Dan Xie, State Key Laboratory of Oncology in
South China, Cancer Center, Sun Yat-Sen University, no. 651, Dongfeng Road
East, Guangzhou, 510060, China. Email: [email protected]
ABSTRACT
Background and Aim: Hepatocellular carcinoma (HCC) is a common human cancer
worldwide. The levels of serum clusterin in HCC patients and its potential
diagnostic significance is not clear. We aimed to evaluate the clinical use of
serum clusterin levels as a surveillance tool for HCC with hepatitis B virus
(HBV) related cirrhosis.
Methods: Twenty-two cases of healthy subjects, 31 cases of HBV carriers, 26
patients with chronic hepatitis B, 29 patients with cirrhosis, and 76 patients
with HCC were enrolled in this study. Serum levels of clusterin were measured
by a sandwich enzyme-linked immunosorbent assay.
Results: The serum clusterin levels in HCC patients were significantly lower
than that in healthy, HBV carriers and chronic hepatitis B, but statistically
higher than in cirrhosis patients. Receiver operator characteristic (ROC)
curve indicated that a serum clusterin value of 50 µg/mL yielded the best
sensitivity (91%) and specificity (83%) for differentiating HCC patients with
HBV-related cirrhosis from those with HBV-related cirrhosis. The optimal alpha
fetoprotein (AFP) cutoff value was 15 ng/mL and was inferior to the clusterin
value of 50 µg/mL, the area under the ROC curves being 0.937 versus 0.781,
respectively (P < 0.05).
Conclusions: Serum clusterin was more sensitive and specific than serum AFP
for differentiating HCC patients with HBV-related cirrhosis from those with
HBV-related liver cirrhosis, and may be a useful surveillance tool of HCC
based on HBV-related cirrhosis.
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Accepted for publication 16 November 2009.
DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1440-1746.2009.06205