欢畅团

齐欢畅2

齐欢畅2

近期开始准备将有关蔡老师药物的有关搜集资料发布在这里，期望能解开真伪。我没有肯定也没有否定。有兴趣的战友可以参与讨论并给我一些意见。泼冷水的就不要来了——滚！那些所谓的理性人也别来掺和了。

[ 本帖最后由 齐欢畅2 于 2010-6-20 10:35 编辑 ]

齐欢畅2

上次和蔡老师谈硝错尼特的时候，他用了杀虫子三个字。
按照他所说，他父亲用过小错尼特的话。
很有可能是这样的。他父亲做试验的思路就是在杀虫子的药物中筛选治乙肝的药物。
而且我敢肯定，他不是一下子就找到了该药物，估计是找了很久才找到的。也就是用了很多“小白人”在“非法”的条件下，做了很多人体药物试验————现在没这个条件了，以前可以。
该类药物成员。我估计就在这个名单里了。
硝基咪唑类药物google搜出来的。
米索硝唑  替伐硝唑  左旋奥硝唑  
女宝  氧氟沙星替硝唑  硝基咪唑类  
哌莫硝唑  替硝唑  奥硝唑  
沙曲硝唑  替硝唑环丙沙星  苯酰甲硝唑  
塞克硝唑  新肤螨灵霜  甲硝唑  
特硝唑

[ 本帖最后由 齐欢畅2 于 2010-6-20 10:38 编辑 ]

齐欢畅2

wikipedia
Chronic hepatitis B
Nitazoxanide alone has shown preliminary evidence of efficacy in the treatment of chronic hepatitis B over a one year course of therapy.[10] Nitazoxanide 500 mg twice daily resulted in a decrease in serum HBV DNA in all of 4 HBeAg-positive patients, with undetectable HBV DNA in 2 of 4 patients, loss of HBeAg in 3 patients, and loss of HBsAg in one patient. Seven of 8 HBeAg-negative patients treated with nitazoxanide 500 mg twice daily had undetectable HBV DNA and 2 had loss of HBsAg.Additionally, nitazoxanide monotherapy in one case and nitazoxanide plus adefovir in another case resulted in undetectable HBV DNA, loss of HBeAg and loss of HBsAg.[11] These preliminary studies showed a higher rate of HBsAg loss than any currently licensed therapy for chronic hepatitis B.The similar mechanism of action of interferon and nitazoxanide suggest that stand-alone nitazoxanide therapy or nitazoxanide in concert with nucleos(t)ide analogs have the potential to increase loss of HBsAg, which is the ultimate end-point of therapy. A formal phase Ⅱ study is being planned for 2009.[12]

large off label use of alinia (nitazoxanide) has been started, you can see results on medhelp hbv community, it is reported a huge drop of hbsag quantity on hbeag negative hbv and fast hbvdna undetactable in the first 4 weeks of alinia at 1,5-2g daily dose http://www.medhelp.org/posts/Hepatitis-B/alinia/show/1109214

Teran et al.. conducted a study at the Pediatric Center Albina Patinö, a reference hospital in the city of Cochabamba, Bolivia, from August 2007 to February 2008. The study compared nitazoxanide and probiotics in the treatment of acute rotavirus diarrhea. They found Small differences in favor of nitazoxanide in comparison with probiotics and concluded that nitazoxanide is an important treatment option for rotavirus diarrhea.[13]

Romark Laboratories has announced encouraging results from international Phase I and II clinical trials evaluating a controlled release version of nitazoxanide in the treatment of chronic hepatitis C virus infection. The company used 675 mg and 1,350 mg twice daily doses of controlled release nitazoxanide Controlled release nitazoxanide showed favorable safety and tolerability throughout the course of the study, with mild to moderate adverse events. Primarily GI-related adverse events were reported.

Lateef et al.. conducted a study in India that evaluated the effectiveness of nitazoxanide in the treatment of beef tapeworm (Taenia saginata) infection. They concluded that nitazoxanide is a safe, effective, inexpensive, and well-tolerated drug for the treatment of niclosamide- and praziquantel-resistant beef tapeworm (Taenia saginata) infection.[14]

A retrospective review of charts of patients treated with nitazoxanide for trichomoniasis by Michael Dan and Jack D. Sobel demonstrated negative result. They reported three case studies; two of which with metronidazole-resistant infections. In Case 3, they reported the patient to be cured with high divided dose tinidazole therapy. They used a high dosage of the drug (total dose, 14–56 g) than the recommended standard dosage (total dose, 3 g) and observed a significant adverse reaction (poorly tolerated nausea) only with the very high dose (total dose, 56 g). Though the output they got is in favor of safety of the drug but their experience was really disappointing in the treatment of trichomoniasis with nitazoxanide.[15]

齐欢畅2

History
Nitazoxanide was originally discovered in the 1980s by Jean François Rossignol at the Pasteur Institute. Initial studies demonstrated activity versus tapeworms. In vitro studies demonstrated much broader activity. Dr. Rossignol co-founded Romark Laboratories, with the goal of bringing nitazoxanide to market as an anti-parasitic drug. Initial studies in the USA were conducted in collaboration with Unimed Pharmaceuticals, Inc. (Marietta, GA) and focused on development of the drug for treatment of cryptosporidiosis in AIDS. Controlled trials began shortly after the advent of effective anti-retroviral therapies. The trials were abandoned due to poor enrollment and the FDA rejected an application based on uncontrolled studies.

Rather than abandon their efforts, Romark launched an impressive series of controlled trials. No other agent has proven efficacy in the treatment of cryptosporidiosis. However, a placebo-controlled study of nitazoxanide in cryptosporidiosis demonstrated significant clinical improvement in adults and children with mild illness. Among malnourished children in Zambia with chronic cryptosporidiosis, a three-day course of therapy not only led to clinical and parasitologic improvement, but also improved survival. In Zambia and in a study conducted in Mexico, nitazoxanide was not successful in the treatment of cryptosporidiosis in advanced infection with human immunodeficiency virus at the doses used. However, it was effective in patients with higher CD4 counts. Also, higher doses seem to have some effect in uncontrolled and unpublished studies. In treatment of giardiasis, nitazoxanide was superior to placebo and comparable to metronidazole. Nitazoxanide was successful in the treatment of metronidazole-resistant giardiasis. Studies have suggested efficacy in the treatment of cyclosporiasis, isosporiasis, and amebiasis.[1]

渺小渺

纳尔逊·曼德拉——胸襟博大的解放者
支持！曼德拉坐牢二十多年，最终迎来南非解放，
我们现在暂时受歧视，受排挤，但那决不是永远！！！！

齐欢畅2

原帖由 渺小渺 于 2010-6-20 10:47 发表
纳尔逊·曼德拉——胸襟博大的解放者
支持！曼德拉坐牢二十多年，最终迎来南非解放，
我们现在暂时受歧视，受排挤，但那决不是永远！！！！

显然！！！

齐欢畅2

我用Google搜索了硝基咪错类的各种药物，
基本上既含有苯环又含有硝基咪错基团的药物只有一种——苯酰甲硝唑
如果是的话就 这个最有可能了。
硝错尼特是不可能的——他父亲那会中国还没有硝错尼特卖，也不可能网上订购——根本不可能。
要不就是我的推断完全错误，他的药物不在硝基咪错类里，是其他类别的药物，这个我真的不知道了。

dgz2008

苯酰甲硝唑 也是杀虫的，我在网上搜索了一下，没有它和乙肝相关的任何内容。。

战胜无敌

原帖由 齐欢畅2 于 2010-6-20 19:25 发表
我用Google搜索了硝基咪错类的各种药物，
基本上既含有苯环又含有硝基咪错基团的药物只有一种——苯酰甲硝唑
如果是的话就 这个最有可能了。
硝错尼特是不可能的——他父亲那会中国还没有硝错尼特卖，也不可能网上订购 ...

你太有才了，感觉被你猜中了．