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肝胆相照论坛 论坛 学术讨论& HBV English 《蔡荣相关》廉价痤疮药有效阻止HIV《传染病杂志》2010. ...
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《蔡荣相关》廉价痤疮药有效阻止HIV《传染病杂志》2010.4.15 [复制链接]

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发表于 2010-4-22 09:01 |只看该作者
原帖由 走遍四方 于 2010-4-22 08:53 发表

大意是抗生素损害免疫损害肝脏,要小心谨慎对待抗生素药物。。。本人携带期间曾因使用强抗生素导致ALT爆至1000多的教训。

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神仙眷侣 如鱼得水 翡翠丝带 健康之翼

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发表于 2010-4-22 09:04 |只看该作者
Johns Hopkins scientists have found that a safe and inexpensive antibiotic(抗体) in use since the 1970s for treating acne(痤疮,粉刺) effectively targets infected immune cells in which HIV, the virus that causes AIDS, lies dormant(静止的,休眠的) and prevents them from reactivating and replicating(复制,折叠) . The drug, minocycline(二甲胺四环素) , likely will improve on the current treatment regimens(养生法,生活规则) of HIV-infected patients if used in combination with(与……结合) a standard drug cocktail known as HAART (Highly Active Antiretroviral Therapy高效抗逆转录病毒治疗), according to research published now online and appearing in print April 15 in The Journal of Infectious Diseases. "The powerful advantage to using minocycline is that the virus appears less able to develop drug resistance because minocycline targets cellular pathways not viral proteins," says Janice Clements, Ph.D., Mary Wallace Stanton Professor of Faculty Affairs, vice dean for faculty(能力,科,系), and professor of molecular and comparative pathobiology(病理学) at the Johns Hopkins University School of Medicine.

"The big challenge clinicians deal with now in this country when treating HIV patients is keeping the virus locked in a dormant state," Clements adds. "While HAART is really effective in keeping down active replication, minocycline is another arm of defense against the virus."

Unlike the drugs used in HAART which target the virus, minocycline homes in on, and adjusts T cells, major immune system agents and targets of HIV infection. According to Clements, minocycline reduces the ability of T cells to activate and proliferate(增殖,扩散) , both steps crucial to HIV production and progression toward full blown AIDS.

If taken daily for life, HAART usually can protect people from becoming ill, but it's not a cure. The HIV virus is kept at a low level but isn't ever entirely purged; it stays quietly hidden in some immune cells. If a person stops HAART or misses a dose, the virus can reactivate out of those immune cells and begin to spread.

The idea for using minocycline as an adjunct(修饰语,附属物) to HAART resulted when the Hopkins team learned of research by others on rheumatoid arthritis(风湿性关节炎) patients showing the anti-inflammatory effects of minocycline on T cells. The Hopkins group connected the dots between that study with previous research of their own showing that minocycline treatment had multiple beneficial effects in monkeys infected with SIV(猿猴免疫缺损病毒) , the primate version of HIV. In monkeys treated with minocycline, the virus load in the cerebrospinal fluid(脑脊髓液) , the viral RNA in the brain and the severity of central nervous system disease were significantly decreased. The drug was also shown to affect T cell activation and proliferation.

"Since minocycline reduced T cell activation, you might think it would have impaired the immune systems in the macaques(猕猴,恒河猴) , which are very similar to humans, but we didn't see any deleterious effect(有毒影响) ," says Gregory Szeto, a graduate student in the Department of Cellular and Molecular Medicine working in the Retrovirus Laboratory at Hopkins.

"This drug strikes a good balance and is ideal for HIV because it targets very specific aspects of immune activation."

The success with the animal model prompted the team to study in test tubes whether minocycline treatment affected latency in human T cells infected with HIV. Using cells from HIV-infected humans on HAART, the team isolated the "resting" immune cells and treated half of them with minocycline. Then they counted how many virus particles were reactivated, finding completely undetectable levels in the treated cells versus detectable levels in the untreated cells.

"Minocycline reduces the capability of the virus to emerge from resting infected T cells," Szeto explains. "It prevents the virus from escaping in the one in a million cells in which it lays dormant in a person on HAART, and since it prevents virus activation it should maintain the level of viral latency(潜伏,潜在影响) or even lower it. That's the goal: Sustaining a latent non-infectious state."

The team used molecular markers to discover that minocycline very selectively interrupts certain specific signaling pathways critical for T cell activation. However, the antibiotic doesn't completely obliterate(消灭,冲刷) T cells or diminish their ability to respond to other infections or diseases, which is crucial for individuals with HIV.

"HIV requires T cell activation for efficient replication and reactivation of latent virus," Clement says, "so our new understanding about minocyline's effects on a T cell could help us to find even more drugs that target its signaling pathways."
温故中知新

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神仙眷侣 如鱼得水 翡翠丝带 健康之翼

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发表于 2010-4-22 09:05 |只看该作者
二甲胺四环素        英文名:Minocycline       CAS:10118-90-8       EINECS: -        分子式:C23H27N3O7·别名: 二甲胺四环素        英文名:Minocycline       CAS:10118-90-8       EINECS: -        分子式:C23H27N3O7
·性质:淡黄色不规则固体
·主要用途:临床主要用于尿路感染、胃肠道感染、妇科感染、脓皮病、眼及耳鼻咽喉感染、骨髓炎等
温故中知新

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神仙眷侣 如鱼得水 翡翠丝带 健康之翼

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发表于 2010-4-22 09:07 |只看该作者
温故中知新

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发表于 2010-4-22 09:16 |只看该作者
柳暗花明又一村

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发表于 2010-4-22 09:19 |只看该作者
齐大灾另外的帖子里不是说了吗 NATURE可能不发发表这种初级论文吗,现在关键是找到一份可以发表这篇论文的杂志。

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发表于 2010-4-22 09:24 |只看该作者
一天又一天 真不知道能坚持多久

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发表于 2010-4-22 09:34 |只看该作者
有意思!!!

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色女勋章 心灵港湾 旺旺勋章

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发表于 2010-4-22 10:15 |只看该作者


[ 本帖最后由 lemonades 于 2010-4-26 00:05 编辑 ]
人的价值=尊严+爱

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版主勋章 勤于助新 携手同心 文思泉涌 锄草勋章

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发表于 2010-4-22 10:58 |只看该作者
原帖由 lemonades 于 2010-4-22 10:15 发表
其实也可以去试试,住在医院里用药,随时观测指标。好歹知道这个药是不是有效,说不准能开辟一条新道路。当然,仅限于现在纤维化程度比较轻的战友。重的还是不要试。 ...

牙会变黄的,大姐。
未成小隐聊中隐,可得长闲胜暂闲。
我本无家更安往,故乡无此好湖山。
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