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增強的肝纖維化評分可對乙型肝炎表面抗原血清清除患者的肝細胞癌風險進行分層
麥龍儀 1 2 , 張嘉誠 1 3 , 許雲軒 1 , 黃家豪 1 2 , 馮志強 1 2 , 袁文峰 1 2 , 瀨戶偉基 1 2 3
隸屬關係
隸屬關係
1
香港大學瑪麗醫院內科。
2
香港大學肝臟研究國家重點實驗室。
3
香港大學深圳醫院內科,中國深圳。
PMID:35594565 DOI:10.1093/cid/ciac387
抽象的
在這項涉及 337 名自發 HBsAg 血清清除 (SC) 的慢性乙型肝炎患者的前瞻性研究中,SC 前的血清增強型肝纖維化 (ELF) 與肝細胞癌 (HCC) 相關(風險比 2.588),ELF <10.8 與 >年齡SC≥50(n = 190)的患者發生 HCC 的風險降低 97%。
關鍵詞:ELF;乙肝病毒;肝癌;功能性治愈。
Enhanced liver fibrosis score stratifies hepatocellular carcinoma risk in patients with hepatitis B surface antigen seroclearance
Lung-Yi Mak 1 2 , Ka-Shing Cheung 1 3 , Rex Wan-Hin Hui 1 , Danny Ka-Ho Wong 1 2 , James Fung 1 2 , Man-Fung Yuen 1 2 , Wai-Kay Seto 1 2 3
Affiliations
Affiliations
1
Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong.
2
State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong.
3
Department of Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
PMID: 35594565 DOI: 10.1093/cid/ciac387
Abstract
In this prospective study involving 337 chronic hepatitis B patients who achieved spontaneous HBsAg seroclearance (SC), serum Enhanced Liver Fibrosis (ELF) before SC was associated with hepatocellular carcinoma (HCC) (hazard ratio 2.588), and ELF <10.8 was associated with >97% reduction in risk of HCC development in patients with ageSC≥50 (n = 190).
Keywords: ELF; HBV; HCC; functional cure.
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