Enhanced liver fibrosis score stratifies hepatocellular carcinoma risk in patients with hepatitis B surface antigen seroclearance
Lung-Yi Mak 1 2 , Ka-Shing Cheung 1 3 , Rex Wan-Hin Hui 1 , Danny Ka-Ho Wong 1 2 , James Fung 1 2 , Man-Fung Yuen 1 2 , Wai-Kay Seto 1 2 3
Affiliations
Affiliations
1
Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong.
2
State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong.
3
Department of Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
PMID: 35594565 DOI: 10.1093/cid/ciac387
Abstract
In this prospective study involving 337 chronic hepatitis B patients who achieved spontaneous HBsAg seroclearance (SC), serum Enhanced Liver Fibrosis (ELF) before SC was associated with hepatocellular carcinoma (HCC) (hazard ratio 2.588), and ELF <10.8 was associated with >97% reduction in risk of HCC development in patients with ageSC≥50 (n = 190).