肝脂肪变性对血清丙氨酸转氨酶水平正常的慢性乙型肝炎患

StephenW

肝脂肪变性对血清丙氨酸转氨酶水平正常的慢性乙型肝炎患者肝脏硬度测量的影响：一项多中心队列研究
王晓东，潘成伟，周桂玉，等
病毒性肝炎杂志|2021 年 12 月 24 日
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期刊摘要

慢性乙型肝炎 (CHB) 患者通常表现出肝脏脂肪变性，研究人员在此研究了其对肝脏硬度测量 (LSM) 的影响，如瞬态弹性成像评估。

    这项研究包括 755 名患有 CHB 且血清丙氨酸转氨酶水平正常的患者，他们接受了振动控制的瞬时弹性成像和肝活检。

    在 286 名 (37.9%) 患者中发现了肝脏脂肪变性。

    观察到肝脏脂肪变性的存在与较高的 BMI 和较高的血清总胆固醇和甘油三酯水平存在独立关联。

    肝脏脂肪变性与纤维化阶段没有显着关联。

    较高的 LSM 与年龄、BMI、血清 γ-谷氨酰转肽酶、HBeAg 阳性以及肝纤维化分期、炎症活动分级独立相关，而肝脂肪变性程度与 LSM 无显着相关性。

    总体研究结果表明，肝脂肪变性对血清丙氨酸转氨酶水平正常的 CHB 患者的瞬时弹性成像测量的 LSM 没有显着影响。

StephenW

Effect of liver steatosis on liver stiffness measurement in chronic hepatitis B patients with normal serum alanine aminotransferase levels: A multicenter cohort study
Wang XD, Pan CW, Zhou GY, et al
Journal of Viral Hepatitis|December 24, 2021
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Journal Summary

Patients with chronic hepatitis B (CHB) commonly show liver steatosis, researchers herein investigated its effect on liver stiffness measurement (LSM), as assessed by transient elastography.

    This study was performed including 755 patients with CHB and normal serum alanine aminotransferase levels, who underwent vibration-controlled transient elastography and liver biopsy.

    Liver steatosis was identified in 286 (37.9%) patients.

    An independent association of presence of liver steatosis was observed with greater BMI, and higher serum total cholesterol and triglyceride levels.

    Liver steatosis showed no significant association with fibrosis stage.

    Higher LSM was recorded in independent correlation with age, BMI, serum gamma-glutamyl-transpeptidase, positivity for HBeAg, as well as liver fibrosis stage, and inflammation activity grade, while there appeared no significant correlation of degree of liver steatosis with LSM.

    Overall findings suggest no significant effect of liver steatosis on transient elastography-measured LSM in CHB patients with normal serum alanine aminotransferase levels.