Effect of liver steatosis on liver stiffness measurement in chronic hepatitis B patients with normal serum alanine aminotransferase levels: A multicenter cohort study
Wang XD, Pan CW, Zhou GY, et al
Journal of Viral Hepatitis|December 24, 2021
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Journal Summary
Patients with chronic hepatitis B (CHB) commonly show liver steatosis, researchers herein investigated its effect on liver stiffness measurement (LSM), as assessed by transient elastography.
This study was performed including 755 patients with CHB and normal serum alanine aminotransferase levels, who underwent vibration-controlled transient elastography and liver biopsy.
Liver steatosis was identified in 286 (37.9%) patients.
An independent association of presence of liver steatosis was observed with greater BMI, and higher serum total cholesterol and triglyceride levels.
Liver steatosis showed no significant association with fibrosis stage.
Higher LSM was recorded in independent correlation with age, BMI, serum gamma-glutamyl-transpeptidase, positivity for HBeAg, as well as liver fibrosis stage, and inflammation activity grade, while there appeared no significant correlation of degree of liver steatosis with LSM.
Overall findings suggest no significant effect of liver steatosis on transient elastography-measured LSM in CHB patients with normal serum alanine aminotransferase levels.