慢性乙型肝炎病毒感染的当前和潜在治疗方法回顾

StephenW

慢性乙型肝炎病毒感染的当前和潜在治疗方法回顾
Eugenia Tsai, MD
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摘要：慢性乙型肝炎病毒 (HBV) 感染仍然是全球主要的健康负担。尽管有效的预防性疫苗广泛可用，但仍有数百万人面临慢性 HBV 感染并发症的风险。目前可用的 HBV 感染治疗方法——干扰素和核苷（酸）类似物——可有效抑制病毒复制并降低肝硬化风险。然而，这些治疗有许多局限性，因此需要替代治疗剂。药物治疗的最新进展预示着慢性 HBV 感染的新治疗方法的新视野，目前有几种有希望的抗病毒和免疫调节剂正在临床前或临床试验中。本文回顾了 HBV 治疗的现状，并重点介绍了旨在直接针对 HBV 或改善慢性感染期间免疫反应的最新治疗策略。
关键词：乙型肝炎病毒，慢性乙型肝炎病毒，衣壳抑制剂，siRNA，免疫治疗

StephenW

Review of Current and Potential Treatments for Chronic Hepatitis B Virus Infection
Eugenia Tsai, MD
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Abstract: Chronic hepatitis B virus (HBV) infection remains a major global health burden. Millions of people are at risk for complications of chronic HBV infection, despite the widespread availability of an effective prophylactic vaccine. The current available treatments for HBV infection—interferon and nucleos(t)ide analogues—are effective at suppressing viral replication and decreasing the risk of cirrhosis. However, these treatments have a number of limitations, creating the need for alternative therapeutic agents. Recent advances in drug therapy have heralded a new horizon of novel therapeutic approaches for chronic HBV infection, with several promising antiviral and immunomodulatory agents currently in preclinical or clinical testing. This article reviews the current landscape of HBV treatments and highlights the most recent therapeutic strategies designed to directly target HBV or to improve immune response during chronic infection.
Keywords: Hepatitis B virus, chronic hepatitis B virus, capsid inhibitors, siRNA, immunotherapy

StephenW

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475260/

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