Review of Current and Potential Treatments for Chronic Hepatitis B Virus Infection
Eugenia Tsai, MD
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Abstract
Abstract: Chronic hepatitis B virus (HBV) infection remains a major global health burden. Millions of people are at risk for complications of chronic HBV infection, despite the widespread availability of an effective prophylactic vaccine. The current available treatments for HBV infection—interferon and nucleos(t)ide analogues—are effective at suppressing viral replication and decreasing the risk of cirrhosis. However, these treatments have a number of limitations, creating the need for alternative therapeutic agents. Recent advances in drug therapy have heralded a new horizon of novel therapeutic approaches for chronic HBV infection, with several promising antiviral and immunomodulatory agents currently in preclinical or clinical testing. This article reviews the current landscape of HBV treatments and highlights the most recent therapeutic strategies designed to directly target HBV or to improve immune response during chronic infection.
Keywords: Hepatitis B virus, chronic hepatitis B virus, capsid inhibitors, siRNA, immunotherapy作者: StephenW 时间: 2021-10-5 20:11
