病毒性肝炎相关肝细胞癌的危险因素及预防

StephenW

病毒性肝炎相关肝细胞癌的危险因素及预防
张新和1、林冠1、田浩宇2、曾子路1、陈家玉1、蝶黄1、孙继1、郭佳琪1、崔惠鹏1、李以玲1
隶属关系
隶属关系

    1
    中国医科大学第一附属医院消化内科，中国沉阳。
    2
    中国医科大学第三临床教研室，沉阳，中国。

    PMID：34568017 PMCID：PMC8458967 DOI：10.3389/fonc.2021.686962

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抽象的

肝细胞癌（HCC）是世界上常见的癌症，其发病率逐年增加。乙型肝炎病毒 (HBV) 感染和丙型肝炎病毒 (HCV) 感染是 HCC 的重要原因。肝硬化、年龄、性别、吸烟和饮酒以及代谢危险因素都会增加 HBV/HCV 患者的癌症风险。并且病毒载量、APRI、FIB-4和肝脏硬度都可以预测病毒感染患者发生HCC的风险。此外，有效的预防策略对于降低 HCC 的风险至关重要。 HCC的预防主要涉及三级预防策略，而一级预防则是基于标准化的疫苗注射以防止HBV/HCV的发生。消除传播途径和疫苗接种将导致 HCC 发病率下降。二级预防包括对 HBV/HCV 进行有效的抗病毒治疗以防止疾病进展为 HCC，三级预防是积极治疗 HCC 以防止其复发。

关键词：乙肝病毒；丙型肝炎病毒；肝细胞癌;预防;风险因素。

版权所有 © 2021 张、关、田、曾、陈、黄、孙、郭、崔、李。

StephenW

Risk Factors and Prevention of Viral Hepatitis-Related Hepatocellular Carcinoma
Xinhe Zhang  1 , Lin Guan  1 , Haoyu Tian  2 , Zilu Zeng  1 , Jiayu Chen  1 , Die Huang  1 , Ji Sun  1 , Jiaqi Guo  1 , Huipeng Cui  1 , Yiling Li  1
Affiliations
Affiliations

    1
    Gastroenterology Department, The First Affiliated Hospital of China Medical University, Shenyang, China.
    2
    The 3rd Clinical Department of China Medical University, Shenyang, China.

    PMID: 34568017 PMCID: PMC8458967 DOI: 10.3389/fonc.2021.686962

Free PMC article
Abstract

Hepatocellular carcinoma (HCC) is a common cancer in the world, and its incidence is increasing yearly. Hepatitis B virus (HBV) infection and hepatitis C virus (HCV) infection are important causes of HCC. Liver cirrhosis, age, sex, smoking and drinking, and metabolic risk factors will increase the risk of cancer in HBV/HCV patients. And viral load, APRI, FIB-4, and liver stiffness can all predict the risk of HCC in patients with viral infection. In addition, effective prevention strategies are essential in reducing the risk of HCC. The prevention of HCC involves mainly tertiary prevention strategies, while the primary prevention is based on standardized vaccine injections to prevent the occurrence of HBV/HCV. Eliminating the route of transmission and vaccination will lead to a decrease in the incidence of HCC. Secondary prevention involves effective antiviral treatment of HBV/HCV to prevent the disease from progressing to HCC, and tertiary prevention is actively treating HCC to prevent its recurrence.

Keywords: hepatitis B virus; hepatitis C virus; hepatocellular carcinoma; prevention; risk factors.

Copyright © 2021 Zhang, Guan, Tian, Zeng, Chen, Huang, Sun, Guo, Cui and Li.

StephenW

https://www.frontiersin.org/articles/10.3389/fonc.2021.686962/pdf