慢性乙型肝炎病毒感染和纤维化：诊断和风险分层的新型非

StephenW

Chronic hepatitis B virus infection and fibrosis: novel non-invasive approaches for diagnosis and risk stratification
Francesco Stalla  1 , Angelo Armandi  1 , Chiara Marinoni  1 , Sharmila Fagoonee  2 , Rinaldo Pellicano  3 , Gian Paolo Caviglia  4
Affiliations
Affiliations

    1
    Department of Medical Sciences, University of Turin, Turin, Italy.
    2
    Institute of Biostructure and Bioimaging, National Research Council, Molecular Biotechnology Center, Torino, Italy.
    3
    Division of Gastroenterology, Molinette Hospital - Città della Salute e della Scienza di Torino, Turin, Italy.
    4
    Department of Medical Sciences, University of Turin, Turin, Italy - [email protected].

    PMID: 33871225 DOI: 10.23736/S2724-5985.21.02911-9

Abstract

Despite the availability of an effective vaccination, chronic hepatitis B virus (HBV) infection is still a major health concern worldwide. Chronic HBV infection can lead to fibrosis accumulation and overtime to cirrhosis, the principal risk factor for liver failure and hepatocellular carcinoma development. Liver biopsy is still considered the gold standard for fibrosis assessment, even though it is invasive and not exempt of complications. Overtime, several non-invasive methods for the detection of liver fibrosis have been developed and gradually introduced into clinical practice. However, their main limitation is the poor performance for the detection of intermediate stages of fibrosis. Finally, novel serological biomarkers, polygenic risk scores and imaging methods have been proposed in last years as novel promising tools to correctly identify the degree of liver fibrosis and to monitor liver disease progression. In this narrative review, we provide an overview on the novel non-invasive approaches for the evaluation of liver fibrosis and risk stratification of patients with chronic hepatitis B.

StephenW

慢性乙型肝炎病毒感染和纤维化：诊断和风险分层的新型非侵入性方法
Francesco Stalla 1，Angelo Armandi 1，Chiara Marinoni 1，Sharmila Fagoonee 2，Rinaldo Pellicano 3，Gian Paolo Caviglia 4
隶属关系
隶属关系

    1个
    意大利都灵都灵大学医学系。
    2个
    意大利都灵分子生物技术中心国家研究委员会生物结构与生物成像研究所。
    3
    意大利都灵Molinette医院胃肠病科-都灵都灵（Cittàdella Salute e della Scienza di Torino）。
    4
    意大利都灵都灵大学医学系[email protected]。

    PMID：33871225 DOI：10.23736 / S2724-5985.21.02911-9

抽象的

尽管可以进行有效的疫苗接种，但慢性乙型肝炎病毒（HBV）感染仍然是全球范围内的主要健康问题。慢性HBV感染可导致肝纤维化累积和加班至肝硬化，这是肝功能衰竭和肝细胞癌发展的主要危险因素。肝活检仍被认为是纤维化评估的金标准，即使它是侵入性的且不能免除并发症。随着时间的流逝，已经开发了几种用于检测肝纤维化的非侵入性方法，并将其逐步引入临床实践。但是，它们的主要局限性在于其对纤维化中间阶段的检测性能较差。最后，近年来，已经提出了新颖的血清生物标志物，多基因风险评分和成像方法，作为正确鉴定肝纤维化程度和监测肝病进展的新颖有前途的工具。在这篇叙述性综述中，我们提供了一种新型的非侵入性方法，用于评估慢性乙型肝炎患者的肝纤维化和危险分层。