Chronic hepatitis B virus infection and fibrosis: novel non-invasive approaches for diagnosis and risk stratification
Francesco Stalla 1 , Angelo Armandi 1 , Chiara Marinoni 1 , Sharmila Fagoonee 2 , Rinaldo Pellicano 3 , Gian Paolo Caviglia 4
Affiliations
Affiliations
1
Department of Medical Sciences, University of Turin, Turin, Italy.
2
Institute of Biostructure and Bioimaging, National Research Council, Molecular Biotechnology Center, Torino, Italy.
3
Division of Gastroenterology, Molinette Hospital - Città della Salute e della Scienza di Torino, Turin, Italy.
4
Department of Medical Sciences, University of Turin, Turin, Italy - [email protected].
Despite the availability of an effective vaccination, chronic hepatitis B virus (HBV) infection is still a major health concern worldwide. Chronic HBV infection can lead to fibrosis accumulation and overtime to cirrhosis, the principal risk factor for liver failure and hepatocellular carcinoma development. Liver biopsy is still considered the gold standard for fibrosis assessment, even though it is invasive and not exempt of complications. Overtime, several non-invasive methods for the detection of liver fibrosis have been developed and gradually introduced into clinical practice. However, their main limitation is the poor performance for the detection of intermediate stages of fibrosis. Finally, novel serological biomarkers, polygenic risk scores and imaging methods have been proposed in last years as novel promising tools to correctly identify the degree of liver fibrosis and to monitor liver disease progression. In this narrative review, we provide an overview on the novel non-invasive approaches for the evaluation of liver fibrosis and risk stratification of patients with chronic hepatitis B. 作者: StephenW 时间: 2021-4-21 15:13
慢性乙型肝炎病毒感染和纤维化：诊断和风险分层的新型非侵入性方法
Francesco Stalla 1，Angelo Armandi 1，Chiara Marinoni 1，Sharmila Fagoonee 2，Rinaldo Pellicano 3，Gian Paolo Caviglia 4
隶属关系
隶属关系
1个
意大利都灵都灵大学医学系。
2个
意大利都灵分子生物技术中心国家研究委员会生物结构与生物成像研究所。
3
意大利都灵Molinette医院胃肠病科-都灵都灵（Cittàdella Salute e della Scienza di Torino）。
4
意大利都灵都灵大学医学系[email protected]。