肝细胞癌患者不同乙型肝炎病毒整合频率的概况

StephenW

Profile of different Hepatitis B virus integration frequency in hepatocellular carcinoma patients
Weiyang Li  1 , Yanwei Qi  2 , Hanshi Xu  3 , Wei Wei  4 , Xiaofang Cui  5
Affiliations
Affiliations

    1
    Jining Medical University, Jining, Shandong, 272067, China; Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining Medical University, Jining, Shandong, 272067, China. Electronic address: [email protected].
    2
    Jining Medical University, Jining, Shandong, 272067, China. Electronic address: [email protected].
    3
    Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China. Electronic address: [email protected].
    4
    Jining Medical University, Jining, Shandong, 272067, China. Electronic address: [email protected].
    5
    Jining Medical University, Jining, Shandong, 272067, China; Shandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jining, Shandong, 272067, China. Electronic address: [email protected].

    PMID: 33773138 DOI: 10.1016/j.bbrc.2021.03.056

Free article
Abstract

Hepatitis B virus (HBV) DNA integration is closely related to the occurrence of liver cancer. However, current studies mostly focus on the detection of the viral integration sites, ignoring the relationship between the frequency of viral integration and liver cancer. Thus, this study uses previous data to distinguish the breakpoints according to the integration frequency and analyzes the characteristics of different groups. This analysis revealed that three sets of breakpoints were characterized by its own integrated sample frequency, breakpoint distribution, and affected gene pathways. This result indicated an evolution in the virus integration sites in the process of tumor formation and development. Therefore, our research clarified the characteristics and differences in the sites of viral integration in tumors and adjacent tissues, and clarified the key signaling pathways affected by viral integration. Hence, these findings might be of great significance in the understanding of the role of viral integration frequency in hepatocellular carcinoma.

Keywords: HBV; HBV DNA integration; Hepatocellular carcinoma; Integration breakpoints; Integration frequency.

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

StephenW

肝细胞癌患者不同乙型肝炎病毒整合频率的概况
李未央1，齐彦伟2，徐汉诗3，魏伟4，崔小芳5
隶属关系
隶属关系

    1个
    济宁医科大学，山东济宁272067；济宁医科大学山东省出生缺陷研究与转化协同创新中心，山东济宁，272067。电子地址：[email protected]。
    2个
    济宁医科大学，山东济宁272067电子地址：[email protected]。
    3
    中山大学肿瘤防治中心鼻咽癌科，广东广州电子地址：[email protected]。
    4
    济宁医科大学，山东济宁272067电子地址：[email protected]。
    5
    济宁医科大学，山东济宁272067；济宁医科大学心理卫生学院，山东省行为医学重点实验室，山东济宁，272067。电子地址：[email protected]。

    PMID：33773138 DOI：10.1016 / j.bbrc.2021.03.056

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抽象的

乙型肝炎病毒（HBV）DNA整合与肝癌的发生密切相关。但是，当前的研究主要集中在病毒整合位点的检测上，而忽略了病毒整合频率与肝癌之间的关系。因此，本研究使用先前的数据根据​​积分频率来区分断点，并分析不同组的特征。该分析表明，三组断点的特征在于其自身的集成采样频率，断点分布和受影响的基因途径。该结果表明在肿瘤形成和发展过程中病毒整合位点的进化。因此，我们的研究阐明了肿瘤和邻近组织中病毒整合位点的特征和差异，并阐明了受病毒整合影响的关键信号通路。因此，这些发现对于了解病毒整合频率在肝细胞癌中的作用可能具有重要意义。

关键字：乙肝病毒； HBV DNA整合；肝细胞癌；集成断点；积分频率。

版权所有©2021作者。由Elsevier Inc.出版。保留所有权利。

StephenW

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