Profile of different Hepatitis B virus integration frequency in hepatocellular carcinoma patients
Weiyang Li 1 , Yanwei Qi 2 , Hanshi Xu 3 , Wei Wei 4 , Xiaofang Cui 5
Affiliations
Affiliations
1
Jining Medical University, Jining, Shandong, 272067, China; Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining Medical University, Jining, Shandong, 272067, China. Electronic address: [email protected].
2
Jining Medical University, Jining, Shandong, 272067, China. Electronic address: [email protected].
3
Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China. Electronic address: [email protected].
4
Jining Medical University, Jining, Shandong, 272067, China. Electronic address: [email protected].
5
Jining Medical University, Jining, Shandong, 272067, China; Shandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jining, Shandong, 272067, China. Electronic address: [email protected].
PMID: 33773138 DOI: 10.1016/j.bbrc.2021.03.056
Free article
Abstract
Hepatitis B virus (HBV) DNA integration is closely related to the occurrence of liver cancer. However, current studies mostly focus on the detection of the viral integration sites, ignoring the relationship between the frequency of viral integration and liver cancer. Thus, this study uses previous data to distinguish the breakpoints according to the integration frequency and analyzes the characteristics of different groups. This analysis revealed that three sets of breakpoints were characterized by its own integrated sample frequency, breakpoint distribution, and affected gene pathways. This result indicated an evolution in the virus integration sites in the process of tumor formation and development. Therefore, our research clarified the characteristics and differences in the sites of viral integration in tumors and adjacent tissues, and clarified the key signaling pathways affected by viral integration. Hence, these findings might be of great significance in the understanding of the role of viral integration frequency in hepatocellular carcinoma.