普通人群中血清维生素D含量低与晚期肝病相关–前瞻性研究

StephenW

Low serum vitamin D level associated with incident advanced liver disease in the general population – a prospective study
Ville Männistö ORCID Icon, Tuija Jääskeläinen , Martti Färkkilä ORCID Icon, Antti Jula , Satu Männistö , Annamari Lundqvist , show all
Received 14 Oct 2020, Accepted 04 Jan 2021, Published online: 21 Jan 2021

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Abstract
Background

Vitamin D deficiency is a common finding in chronic liver disease. It has also been linked to the pathogenesis of non-alcoholic fatty liver disease, hepatic fibrogenesis, decompensation and hepatocellular carcinoma.
Aims

We analyzed whether serum vitamin D is associated with incident advanced liver disease in the general population.
Methods

Serum 25-hydroxyvitamin D was measured in 13807 individuals participating in the Finnish population-based health examination surveys FINRISK 1997 and Health 2000. Data were linked with incident advanced liver disease (hospitalization, cancer or death related to liver disease). During a follow-up of 201444 person-years 148 severe liver events occurred. Analyses were performed using multivariable Cox regression analyses.
Results

Vitamin D level associated with incident advanced liver disease with the hazard ratio of 0.972 (95% confidence interval 0.943-0.976, p < .001), when adjusted for age, sex, blood sampling season and stratified by cohort.The association remained robust and significant in multiple different adjustment models adjusting sequentially for 22 potential confounders.
Conclusion

Low vitamin D level is linked to incident advanced liver disease at population level.

StephenW

普通人群中血清维生素D含量低与晚期肝病相关–前瞻性研究
VilleMännistöORCID图标，TuijaJääskeläinen，MarttiFärkkiläORCID图标，Antti Jula，SatuMännistö，Annamari Lundqvist，显示全部
2020年10月14日收到，2021年1月4日接受，在线发布：2021年1月21日

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抽象
背景

维生素D缺乏症是慢性肝病的常见发现。它也与非酒精性脂肪肝，肝纤维化，代偿失调和肝细胞癌的发病机理有关。
目的

我们分析了普通人群中血清维生素D是否与晚期肝病相关。
方法

在参加FINRISK 1997和Health 2000的芬兰人群健康检查中，对13807个人进行了血清25-羟基维生素D的测量。数据与晚期肝病（住院，癌症或与肝病相关的死亡）相关。在201444人年的随访中，发生了148起严重的肝脏事件。使用多变量Cox回归分析进行分析。
结果

经年龄，性别，采血季节和按人群分组后，维生素D水平与晚期肝病相关，危险比为0.972（95％置信区间0.943-0.976，p <0.001），相关性保持稳健和稳定。在针对22个潜在混杂因素进行顺序调整的多个不同调整模型中具有重要意义。
结论

维生素D水平低与人群水平的晚期肝病有关。