Low serum vitamin D level associated with incident advanced liver disease in the general population – a prospective study
Ville Männistö ORCID Icon, Tuija Jääskeläinen , Martti Färkkilä ORCID Icon, Antti Jula , Satu Männistö , Annamari Lundqvist , show all
Received 14 Oct 2020, Accepted 04 Jan 2021, Published online: 21 Jan 2021
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Abstract
Background
Vitamin D deficiency is a common finding in chronic liver disease. It has also been linked to the pathogenesis of non-alcoholic fatty liver disease, hepatic fibrogenesis, decompensation and hepatocellular carcinoma.
Aims
We analyzed whether serum vitamin D is associated with incident advanced liver disease in the general population.
Methods
Serum 25-hydroxyvitamin D was measured in 13807 individuals participating in the Finnish population-based health examination surveys FINRISK 1997 and Health 2000. Data were linked with incident advanced liver disease (hospitalization, cancer or death related to liver disease). During a follow-up of 201444 person-years 148 severe liver events occurred. Analyses were performed using multivariable Cox regression analyses.
Results
Vitamin D level associated with incident advanced liver disease with the hazard ratio of 0.972 (95% confidence interval 0.943-0.976, p < .001), when adjusted for age, sex, blood sampling season and stratified by cohort.The association remained robust and significant in multiple different adjustment models adjusting sequentially for 22 potential confounders.
Conclusion
Low vitamin D level is linked to incident advanced liver disease at population level. 作者: StephenW 时间: 2021-1-22 21:04