正常碱性磷酸酶水平取决于种族/民族

StephenW

          Normal alkaline phosphatase levels are dependent on race/ethnicity                    

                                                      Jan 7, 2021                                 

                          
Normal alkaline phosphatase levels are dependent on race/ethnicity: National Health and Nutrition Examination Survey data
Objective
The range of normal serum alkaline phosphatase is not well defined. We used data from the National Health and Nutrition Examination Survey from 2009 to 2016 to generate normal ranges for a racially diverse sample of healthy adults.
Methods
Respondents 18 years or older were included. Conditions known to elevate alkaline phosphatase were cause for exclusion. Alkaline phosphatase was measured using a colorimetric method based on standardised National Health and Nutrition Examination Survey protocols. Because alkaline phosphatase values were not normally distributed, log transformation was used. We calculated upper limits of normal (97.5 percentile), stratified by sex and race/ethnicity, and 90% CIs for the upper limits of normal.
Results
1199 respondents (673 female, 526 male) had body mass index from 18.5 to less than 25. Upper limits of normal were highest among Hispanics (123.2 IU/L (90% CI 110.2 to 136.7) for females; 123.8 IU/L (90% CI 112.0 to 135.1) for males), followed by African Americans (109.9 IU/L (90% CI 97.3 to 122.4) for females; 116.3 IU/L (90% CI 105.0 to 126.1) for males) and whites (97.1 IU/L (90% CI 91.0 to 103.4) for females; 109.6 IU/L (90% CI 102.1 to 116.3) for males). Asian American/Pacific Islander respondents had the lowest results: 93.8 IU/L (90% CI 88.2 to 99.5) for females and 95.3 IU/L (90% CI 88.1 to 102.1) for males.
Conclusions
The upper limit of normal alkaline phosphatase varies by race/ethnicity in a large US sample with body mass index of 18.5<25.

StephenW

正常碱性磷酸酶水平取决于种族/民族

2021年1月7日

正常碱性磷酸酶水平取决于种族/民族：国家健康与营养检查数据

目的
正常血清碱性磷酸酶的范围没有明确定义。我们使用了2009年至2016年国家健康与营养调查的数据，为种族不同的健康成年人样本生成了正常范围。

方法
包括18岁或以上的受访者。导致碱性磷酸酶升高的条件被排除在外。碱性磷酸酶是使用比色法根据标准的国家健康和营养检查协议进行测量的。由于碱性磷酸酶的值不呈正态分布，因此使用对数转换。我们按性别和种族/民族对分层的正常上限（97.5％）和正常上限的90％CI进行了计算。

结果
1199名受访者（673名女性，526名男性）的体重指数从18.5到小于25。西班牙裔人的正常上限最高（123.2 IU / L（90％CI 110.2至136.7））；女性为123.8 IU / L（90 CI（男性为112.0至135.1％），其次是非洲裔美国人（女性为109.9 IU / L（90％CI 97.3至122.4）；男性为116.3 IU / L（90％CI 105.0至126.1））和白人（97.1 IU） / L（女性为90％CI 91.0至103.4）； 109.6 IU / L（男性为90％CI 102.1至116.3）。亚裔美国人/太平洋岛民受访者的结果最低：女性为93.8 IU / L（90％CI 88.2至99.5），男性为95.3 IU / L（90％CI 88.1至102.1）。

结论
在体重指数为18.5 <25的大型美国样本中，正常碱性磷酸酶的上限因种族/民族而异。