Normal alkaline phosphatase levels are dependent on race/ethnicity
Jan 7, 2021
Normal alkaline phosphatase levels are dependent on race/ethnicity: National Health and Nutrition Examination Survey data Objective
The range of normal serum alkaline phosphatase is not well defined. We used data from the National Health and Nutrition Examination Survey from 2009 to 2016 to generate normal ranges for a racially diverse sample of healthy adults. Methods
Respondents 18 years or older were included. Conditions known to elevate alkaline phosphatase were cause for exclusion. Alkaline phosphatase was measured using a colorimetric method based on standardised National Health and Nutrition Examination Survey protocols. Because alkaline phosphatase values were not normally distributed, log transformation was used. We calculated upper limits of normal (97.5 percentile), stratified by sex and race/ethnicity, and 90% CIs for the upper limits of normal. Results
1199 respondents (673 female, 526 male) had body mass index from 18.5 to less than 25. Upper limits of normal were highest among Hispanics (123.2 IU/L (90% CI 110.2 to 136.7) for females; 123.8 IU/L (90% CI 112.0 to 135.1) for males), followed by African Americans (109.9 IU/L (90% CI 97.3 to 122.4) for females; 116.3 IU/L (90% CI 105.0 to 126.1) for males) and whites (97.1 IU/L (90% CI 91.0 to 103.4) for females; 109.6 IU/L (90% CI 102.1 to 116.3) for males). Asian American/Pacific Islander respondents had the lowest results: 93.8 IU/L (90% CI 88.2 to 99.5) for females and 95.3 IU/L (90% CI 88.1 to 102.1) for males. Conclusions
The upper limit of normal alkaline phosphatase varies by race/ethnicity in a large US sample with body mass index of 18.5<25. 作者: StephenW 时间: 2021-1-9 21:02
结果
1199名受访者(673名女性,526名男性)的体重指数从18.5到小于25。西班牙裔人的正常上限最高(123.2 IU / L(90%CI 110.2至136.7));女性为123.8 IU / L(90 CI(男性为112.0至135.1%),其次是非洲裔美国人(女性为109.9 IU / L(90%CI 97.3至122.4);男性为116.3 IU / L(90%CI 105.0至126.1))和白人(97.1 IU) / L(女性为90%CI 91.0至103.4); 109.6 IU / L(男性为90%CI 102.1至116.3)。亚裔美国人/太平洋岛民受访者的结果最低:女性为93.8 IU / L(90%CI 88.2至99.5),男性为95.3 IU / L(90%CI 88.1至102.1)。