致編輯的信：檢查NA治療期間的HBV RNA動力學-NA多功能抗病毒

StephenW

Hepatology

. 2020 Nov 13.
doi: 10.1002/hep.31627. Online ahead of print.
Letter to the Editor: Examining HBV RNA kinetics during NA treatment - are NA multifunctional antiviral agents?
Harel Dahari  1 , Andrew Vaillant  2 , Scott J Cotler  1
Affiliations
Affiliations

    1
    The Program for Experimental & Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
    2
    Replicor Inc, 6100 Royalmount Avenue, Montreal, Quebec, Canada, H4P 2R2.

    PMID: 33184892 DOI: 10.1002/hep.31627

Abstract

Carey et al1 recently proposed that HBV pregenomic RNA (pgRNA) is a sensitive indicator of covalently closed circular DNA (cccDNA) transcription status in patients receiving nucleos(t)ide analogue therapy (NA) for hepatitis B. pgRNA is transcribed from the cccDNA minichromosome and therefore reflects a product of cccDNA transcriptional activity and its prevalence within HBV-infected cells. They observed that some patients reached pgRNA negativity 12 months of NA, suggesting a surprisingly rapid decline in transcriptional activity/prevalence of cccDNA.

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肝病學

。 2020年11月13日
doi：10.1002 / hep.31627。在線印刷。
致編輯的信：檢查NA治療期間的HBV RNA動力學-NA多功能抗病毒藥嗎？
Harel Dahari 1，Andrew Vaillant 2，Scott J Cotler 1
隸屬關係
隸屬關係

    1個
    美國伊利諾伊州梅伍德市，洛約拉大學芝加哥分校醫學院，醫學系，肝病科，實驗和理論建模程序。
    2
    Replicor Inc，H4P 2R2，地址為加拿大魁北克省蒙特利爾市皇家山大街6100號。

    PMID：33184892 DOI：10.1002 / hep.31627

抽象

Carey等[1]最近提出，乙型肝炎接受核苷酸類似物療法（NA）的患者中，HBV前基因組RNA（pgRNA）是共價閉合環狀DNA（cccDNA）轉錄狀態的敏感指標。因此，它反映了cccDNA轉錄活性及其在HBV感染細胞中的流行程度的產物。他們觀察到有些患者在NA的12個月時達到pgRNA陰性，這表明cccDNA的轉錄活性/患病率出乎意料地迅速下降。

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