. 2020 Nov 13.
doi: 10.1002/hep.31627. Online ahead of print.
Letter to the Editor: Examining HBV RNA kinetics during NA treatment - are NA multifunctional antiviral agents?
Harel Dahari 1 , Andrew Vaillant 2 , Scott J Cotler 1
Affiliations
Affiliations
1
The Program for Experimental & Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
2
Replicor Inc, 6100 Royalmount Avenue, Montreal, Quebec, Canada, H4P 2R2.
PMID: 33184892 DOI: 10.1002/hep.31627
Abstract
Carey et al1 recently proposed that HBV pregenomic RNA (pgRNA) is a sensitive indicator of covalently closed circular DNA (cccDNA) transcription status in patients receiving nucleos(t)ide analogue therapy (NA) for hepatitis B. pgRNA is transcribed from the cccDNA minichromosome and therefore reflects a product of cccDNA transcriptional activity and its prevalence within HBV-infected cells. They observed that some patients reached pgRNA negativity 12 months of NA, suggesting a surprisingly rapid decline in transcriptional activity/prevalence of cccDNA.
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