- 现金
- 62111 元
- 精华
- 26
- 帖子
- 30437
- 注册时间
- 2009-10-5
- 最后登录
- 2022-12-28
|
J Viral Hepat. 2019 Sep 13. doi: 10.1111/jvh.13210. [Epub ahead of print]
Ovarian HBV replication following ovulation induction in female Hepatitis B carriers undergoing IVF treatment: a prospective observational study.
Mak JSM1, Lao TT1, Leung MBW1, Chung CHS1, Chung JPW1, Cheung LP1, Li TC1.
Author information
1
Assisted Reproduction Technology unit, Prince of Wales Hospital, The Chinese University of Hong Kong.
Abstract
Hepatitis B virus (HBV) can be found in ovarian tissues. This study compared HBV DNA levels in follicular fluid collected during oocyte retrieval with paired serum samples in HBV carriers after ovarian stimulation during IVF treatment for infertility. Sixty-four HBV carrier women referred to the Assisted Reproductive Units of two Hong Kong hospitals were recruited. At oocyte retrieval, the follicular fluid aspirated from the first follicle was collected for study. In 22 women, the first follicular fluid sample from both ovaries were similarly collected and studied. These women were also tested for liver function test and HBeAg. In 28 (43.8%) women, HBV DNA was detected in follicular fluid and the level correlated with serum levels (Spearman's correlation P<0.001). There was concordant detection of HBV DNA in both ovaries, and the levels were significantly correlated (Spearman's correlation P= 0.029). In 40% of women with FF HBV DNA, the follicular fluid:serum ratio was >1.0, suggesting stimulation of HBV replication. These women also had significantly different liver function test results. Increased HBV replication exists in 40% of women with HBV DNA detected in follicular undergoing ovarian stimulation during IVF treatment.
© 2019 John Wiley & Sons Ltd.
KEYWORDS:
Hepatitis B virus infection; in vitro fertilization; ovarian follicles; ovarian stimulation; viral replication
PMID:
31519044
DOI:
10.1111/jvh.13210 |
|