在接受IVF治疗的女性乙型肝炎携带者中，在排卵诱导后卵巢HB

StephenW

J Viral Hepat. 2019 Sep 13. doi: 10.1111/jvh.13210. [Epub ahead of print]
Ovarian HBV replication following ovulation induction in female Hepatitis B carriers undergoing IVF treatment: a prospective observational study.
Mak JSM1, Lao TT1, Leung MBW1, Chung CHS1, Chung JPW1, Cheung LP1, Li TC1.
Author information

1
    Assisted Reproduction Technology unit, Prince of Wales Hospital, The Chinese University of Hong Kong.

Abstract

Hepatitis B virus (HBV) can be found in ovarian tissues. This study compared HBV DNA levels in follicular fluid collected during oocyte retrieval with paired serum samples in HBV carriers after ovarian stimulation during IVF treatment for infertility. Sixty-four HBV carrier women referred to the Assisted Reproductive Units of two Hong Kong hospitals were recruited. At oocyte retrieval, the follicular fluid aspirated from the first follicle was collected for study. In 22 women, the first follicular fluid sample from both ovaries were similarly collected and studied. These women were also tested for liver function test and HBeAg. In 28 (43.8%) women, HBV DNA was detected in follicular fluid and the level correlated with serum levels (Spearman's correlation P<0.001). There was concordant detection of HBV DNA in both ovaries, and the levels were significantly correlated (Spearman's correlation P= 0.029). In 40% of women with FF HBV DNA, the follicular fluid:serum ratio was >1.0, suggesting stimulation of HBV replication. These women also had significantly different liver function test results. Increased HBV replication exists in 40% of women with HBV DNA detected in follicular undergoing ovarian stimulation during IVF treatment.

© 2019 John Wiley & Sons Ltd.
KEYWORDS:

Hepatitis B virus infection; in vitro fertilization; ovarian follicles; ovarian stimulation; viral replication

PMID:
    31519044
DOI:
    10.1111/jvh.13210

StephenW

J病毒肝病。 2019年9月13日doi：10.1111 / jvh.13210。 [印刷前的电子版]
在接受IVF治疗的女性乙型肝炎携带者中，在排卵诱导后卵巢HBV复制：一项前瞻性观察研究。
Mak JSM1，老挝TT1，梁MBW1，Chung CHS1，Chung JPW1，Cheung LP1，Li TC1。
作者信息

1
    协助复制科技组，香港中文大学威尔斯亲王医院。

抽象

在卵巢组织中可以发现乙型肝炎病毒（HBV）。本研究比较了在IVF治疗不孕症期间卵巢刺激后卵母细胞取出过程中收集的卵泡液中的HBV DNA水平与HBV携带者中的配对血清样本。招募了64名HBV携带者妇女，她们被称为两家香港医院的辅助生殖单位。在卵母细胞取出时，收集从第一个卵泡吸出的卵泡液用于研究。在22名女性中，同样收集并研究了来自两个卵巢的第一个卵泡液样本。还对这些女性进行了肝功能检查和HBeAg检测。在28名（43.8％）女性中，在卵泡液中检测到HBV DNA，其水平与血清​​水平相关（Spearman相关性P <0.001）。两个卵巢中的HBV DNA检测结果一致，且水平显着相关（Spearman相关系数P = 0.029）。在40％的患有FF HBV DNA的女性中，卵泡液：血清比率> 1.0，表明刺激了HBV复制。这些女性的肝功能检查结果也有显着差异。在IVF治疗期间卵泡刺激中检测到卵泡中检测到HBV DNA的40％女性中存在HBV复制增加。

©2019 John Wiley＆Sons Ltd.
关键词：

乙型肝炎病毒感染;体外受精;卵巢卵泡;卵巢刺激;病毒复制

结论：
    31519044
DOI：
    10.1111 / jvh.13210