低维生素D水平与慢性乙型肝炎患者的高病毒载量相关：系统

StephenW

Low vitamin D levels are associated with high viral loads in patients with chronic hepatitis B: a systematic review and meta-analysis

    Ye-Chao Hu, Wei-Wei Wang, Wei-Yun Jiang, Chun-Qing Li, Jian-Chun Guo and Yun-Hao XunEmail author

BMC Gastroenterology201919:84

https://doi.org/10.1186/s12876-019-1004-2

©  The Author(s). 2019

    Received: 27 June 2018Accepted: 30 May 2019Published: 11 June 2019

Open Peer Review reports
Abstract
Background

Previous studies have investigated the vitamin D status in patients with chronic hepatitis B virus (HBV) infection and its relationship with HBV replication, the results however were inconsistent. The present meta-analysis was carried out to compare the vitamin D levels between patients with chronic hepatitis B (CHB) and healthy controls, and to determine whether vitamin D levels were correlated with HBV viral loads significantly.
Methods

A systematic search was conducted via PubMed, Web of Science, EMBASE and the Cochrane Library to identify eligible studies until September 28, 2017. We calculated pooled mean difference (MD) and 95% confidence intervals (CI) to quantitatively estimate the difference of vitamin D levels between CHB patients and controls. In addition, correlation between serum vitamin D levels and HBV viral loads was defined by summary correlation coefficient (r value) and the corresponding 95% CI.
Results

A total of 7 studies involving 814 CHB patients and 696 healthy controls were included. A significantly decreased vitamin D levels was found in CHB patients compared with healthy controls: pooled MD (95% CI) was − 2.03 ng/mL (− 2.60, − 1.46). Latitude-stratified subgroup analysis indicated this difference was more obvious in low latitude areas, with a bigger pooled MD (95% CI) of − 2.72 ng/mL (− 4.57, − 0.87). In addition, we observed an inverse correlation between serum vitamin D levels and HBV viral loads: pooled r (95% CI) was − 0.41(− 0.54, − 0.27).
Conclusions

Our results showed that vitamin D levels were lower in CHB patients than that of healthy controls and inversely correlated with HBV viral loads, although future comprehensive studies are needed to clarify the underlying mechanisms.
Keywords

    Hepatitis B virus
    Hepatitis B, chronic
    Vitamin D deficiency
    25-hydroxyvitamin D
    Meta-analysis

StephenW

低维生素D水平与慢性乙型肝炎患者的高病毒载量相关：系统评价和荟萃分析

胡叶超，王伟伟，江伟云，李春青，郭建春，尹云浩，电子邮件作者

BMC Gastroenterology201919：84

Https://doi.org/10.1186/s12876-019-1004-2

©The Author（s）。 2019

收稿日期：2018年6月27日接受日期：2019年5月30日出版日期：2019年6月11日

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抽象
背景

以往的研究调查了慢性乙型肝炎病毒（HBV）感染患者的维生素D状况及其与HBV复制的关系，但结果不一致。本荟萃分析旨在比较慢性乙型肝炎（CHB）患者和健康对照组之间的维生素D水平，并确定维生素D水平是否在HBV病毒载量显着的情况下被检测到。
方法

通过PubMed，Web of Science，EMBASE和Cochrane图书馆进行系统检索，以确定感兴趣的研究，直到2017年9月28日。我们计算了汇总的平均差异（MD）和95％置信区间（CI），以定量估计维生素的差异。 CHB患者和对照之间的D水平。此外，血清维生素D水平与HBV病毒载量之间的相关性由汇总相关系数（r值）和相应的95％CI定义。
结果

共纳入7项研究，涉及814名CHB患者和696名健康对照。与健康对照相比，CHB患者的维生素D水平显着降低：合并的MD（95％CI）为-2.03 ng / mL（ -  2.60， -  1.46）。纬度分层亚组分析表明，这种差异在低纬度地区更为明显，合并MD（95％CI）更大 -  2.72 ng / mL（ -  4.57， -  0.87）。此外，我们观察到血清维生素D水平与HBV病毒载量之间的反向相关性：合并的r（95％CI）为-0.41（-0.54，-0.27）。
结论

我们的结果显示，CHB患者的维生素D水平低于健康对照，与HBV病毒载量成反比，尽管需要进一步的综合研究来阐明其潜在的机制。
关键词

乙型肝炎病毒
乙型肝炎，慢性
维生素D缺乏症
25-羟基维生素D.
Meta分析

StephenW

https://bmcgastroenterol.biomedc ... 6/s12876-019-1004-2

neilhbver

维生素d归类到维生素里可能是错误的，维生素d用途太广泛了，补点绝对有必要