Received: 27 June 2018Accepted: 30 May 2019Published: 11 June 2019
Open Peer Review reports
Abstract
Background
Previous studies have investigated the vitamin D status in patients with chronic hepatitis B virus (HBV) infection and its relationship with HBV replication, the results however were inconsistent. The present meta-analysis was carried out to compare the vitamin D levels between patients with chronic hepatitis B (CHB) and healthy controls, and to determine whether vitamin D levels were correlated with HBV viral loads significantly.
Methods
A systematic search was conducted via PubMed, Web of Science, EMBASE and the Cochrane Library to identify eligible studies until September 28, 2017. We calculated pooled mean difference (MD) and 95% confidence intervals (CI) to quantitatively estimate the difference of vitamin D levels between CHB patients and controls. In addition, correlation between serum vitamin D levels and HBV viral loads was defined by summary correlation coefficient (r value) and the corresponding 95% CI.
Results
A total of 7 studies involving 814 CHB patients and 696 healthy controls were included. A significantly decreased vitamin D levels was found in CHB patients compared with healthy controls: pooled MD (95% CI) was − 2.03 ng/mL (− 2.60, − 1.46). Latitude-stratified subgroup analysis indicated this difference was more obvious in low latitude areas, with a bigger pooled MD (95% CI) of − 2.72 ng/mL (− 4.57, − 0.87). In addition, we observed an inverse correlation between serum vitamin D levels and HBV viral loads: pooled r (95% CI) was − 0.41(− 0.54, − 0.27).
Conclusions
Our results showed that vitamin D levels were lower in CHB patients than that of healthy controls and inversely correlated with HBV viral loads, although future comprehensive studies are needed to clarify the underlying mechanisms.
Keywords
Hepatitis B virus
Hepatitis B, chronic
Vitamin D deficiency
25-hydroxyvitamin D
Meta-analysis
通过PubMed,Web of Science,EMBASE和Cochrane图书馆进行系统检索,以确定感兴趣的研究,直到2017年9月28日。我们计算了汇总的平均差异(MD)和95%置信区间(CI),以定量估计维生素的差异。 CHB患者和对照之间的D水平。此外,血清维生素D水平与HBV病毒载量之间的相关性由汇总相关系数(r值)和相应的95%CI定义。
结果
共纳入7项研究,涉及814名CHB患者和696名健康对照。与健康对照相比,CHB患者的维生素D水平显着降低:合并的MD(95%CI)为-2.03 ng / mL( - 2.60, - 1.46)。纬度分层亚组分析表明,这种差异在低纬度地区更为明显,合并MD(95%CI)更大 - 2.72 ng / mL( - 4.57, - 0.87)。此外,我们观察到血清维生素D水平与HBV病毒载量之间的反向相关性:合并的r(95%CI)为-0.41(-0.54,-0.27)。
结论