ω-3多不饱和脂肪酸对肝切除术患者肝功能和炎症反应的影响

StephenW

Effect of ω-3 polyunsaturated fatty acids on liver function and inflammatory reaction in patients undergoing hepatectomy: a systematic review and meta-analysis of randomized control trials
Chengshuo Zhang, Jianzhen Lin, Feng Li, Yue Li, Baofeng Jiang, Han Bai & show all
Received 28 Nov 2018, Accepted 01 Feb 2019, Accepted author version posted online: 07 Feb 2019

    Download citation https://doi.org/10.1080/17474124.2019.1578648



Accepted author version
Abstract

Introduction: Several studies have investigated the relationship between ω-3 polyunsaturated fatty acids (PUFAs) administration and liver function and inflammatory reaction in patients undergoing liver resection, but the results remain conflicting and inconclusive.

Areas covered: In this meta-analysis, a relevant database search was performed to retrieve all the randomized controlled trials (RCTs) exploring the effect of ω-3 PUFAs administration in patients undergoing hepatectomy until the end of April 2018. A random effect model was used to conduct this meta-analysis with RevMan 5.3.5 software. The quality of evidence for each postoperative outcome was assessed using the GRADEpro analysis.

Expert opinion: 4 RCTs including 553 patients (277 with and 276 without ω-3 PUFAs) were identified. ω-3 PUFAs significantly reduced alanine aminotransferase [Mean difference (MD): -68.82, 95% confidence interval (CI): −108.55 to – 29.08; p=0.0007]; aspartate aminotransferase (MD: -64.92, 95% CI: − 112.87 to −16.98; p=0.008), white blood cell count (MD: −1.22, 95% CI: -2.15 to −0.29; p=0.01) and increased the level of pre-albumin on postoperative day 3 (MD: 10.42, 95% CI: 4.84 to 15.99; p =0.0002). The results indicate that ω-3 PUFAs administration has a positive impact on the liver function and inflammatory reaction in patients undergoing liver resection.
Keywords: hepatectomy, ω-3 polyunsaturated fatty acids, liver function, inflammatory reaction, randomized controlled trails, meta-analysis

StephenW

ω-3多不饱和脂肪酸对肝切除术患者肝功能和炎症反应的影响：随机对照试验的系统评价和荟萃分析
张成硕，林健珍，李枫，李悦，蒋宝峰，韩柏，全部展示
2018年11月28日收到，2019年2月1日接受，接受作者发布在线：2019年2月7日

    下载引文https://doi.org/10.1080/17474124.2019.1578648



接受的作者版本
抽象

简介：一些研究调查了ω-3多不饱和脂肪酸（PUFA）给药与肝功能和炎症反应之间的关系，但结果仍然存在矛盾和不确定性。

涵盖的领域：在这项荟萃分析中，进行了相关的数据库检索以检索所有随机对照试验（RCT），探讨ω-3多不饱和脂肪酸对接受肝切除术的患者的影响，直至2018年4月底。随机效应模型为用于使用RevMan 5.3.5软件进行这种荟萃分析。使用GRADEpro分析评估每个术后结果的证据质量。

专家意见：确定了4项随机对照试验，包括553名患者（277名和276名不含ω-3多不饱和脂肪酸）。 ω-3 PUFA显着降低丙氨酸氨基转移酶[平均差异（MD）： -  68.82,95％置信区间（CI）： -  108.55至-29.08; p值= 0.0007];天冬氨酸氨基转移酶（MD：-64.92,95％CI：-112.87至-16.98; p = 0.008），白细胞计数（MD：-1.22,95％CI：-2.15至-0.29; p = 0.01）并增加术后第3天的前白蛋白水平（MD：10.42,95％CI：4.84至15.99; p = 0.0002）。结果表明，给予ω-3多不饱和脂肪酸对肝切除患者的肝功能和炎症反应有积极影响。
关键词：肝切除术，ω-3多不饱和脂肪酸，肝功能，炎症反应，随机对照试验，荟萃分析