Effect of ω-3 polyunsaturated fatty acids on liver function and inflammatory reaction in patients undergoing hepatectomy: a systematic review and meta-analysis of randomized control trials
Chengshuo Zhang, Jianzhen Lin, Feng Li, Yue Li, Baofeng Jiang, Han Bai & show all
Received 28 Nov 2018, Accepted 01 Feb 2019, Accepted author version posted online: 07 Feb 2019
Introduction: Several studies have investigated the relationship between ω-3 polyunsaturated fatty acids (PUFAs) administration and liver function and inflammatory reaction in patients undergoing liver resection, but the results remain conflicting and inconclusive.
Areas covered: In this meta-analysis, a relevant database search was performed to retrieve all the randomized controlled trials (RCTs) exploring the effect of ω-3 PUFAs administration in patients undergoing hepatectomy until the end of April 2018. A random effect model was used to conduct this meta-analysis with RevMan 5.3.5 software. The quality of evidence for each postoperative outcome was assessed using the GRADEpro analysis.
Expert opinion: 4 RCTs including 553 patients (277 with and 276 without ω-3 PUFAs) were identified. ω-3 PUFAs significantly reduced alanine aminotransferase [Mean difference (MD): -68.82, 95% confidence interval (CI): −108.55 to – 29.08; p=0.0007]; aspartate aminotransferase (MD: -64.92, 95% CI: − 112.87 to −16.98; p=0.008), white blood cell count (MD: −1.22, 95% CI: -2.15 to −0.29; p=0.01) and increased the level of pre-albumin on postoperative day 3 (MD: 10.42, 95% CI: 4.84 to 15.99; p =0.0002). The results indicate that ω-3 PUFAs administration has a positive impact on the liver function and inflammatory reaction in patients undergoing liver resection.
Keywords: hepatectomy, ω-3 polyunsaturated fatty acids, liver function, inflammatory reaction, randomized controlled trails, meta-analysis作者: StephenW 时间: 2019-2-9 07:28