与自然受孕相比，辅助受孕不会增加母婴传播乙型肝炎病毒

StephenW

Fertil Steril. 2019 Feb;111(2):348-356. doi: 10.1016/j.fertnstert.2018.10.021.
Assisted conception does not increase the risk for mother-to-child transmission of hepatitis B virus, compared with natural conception: a prospective cohort study.
Nie R1, Wang M1, Liao T2, Qian K1, Zhu G1, Jin L3.
Author information

1
    Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
2
    Reproductive Medicine Center, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, People's Republic of China.
3
    Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. Electronic address: [email protected].

Abstract
OBJECTIVE:

To determine whether assisted conception increases the risk for mother-to-child transmission of hepatitis B virus (HBV) infection compared with natural conception.
DESIGN:

Prospective cohort study.
SETTING:

Research laboratory.
PATIENT(S):

A total of 305 children, 176 born with assisted conception and 129 born with natural conception, were born to a total of 251 hepatitis B surface antigen- (HBsAg-) positive women.
INTERVENTION(S):

None.
MAIN OUTCOME MEASURE(S):

The seropositive rates of HBsAg in children at birth and HBV infection rates at 9-15 months of age.
RESULT(S):

Overall, 7.5% (23/305) of children were HBsAg-positive at birth. The rate of HBsAg-positive children at birth did not significantly differ between children in the assisted conception group compared with those in the natural conception group (6.3% [11/176] vs. 9.3% [12/129]). Multivariate logistic regression analysis showed that conception method is not related to the rate of HBsAg-positive children at birth. All children who were positive for HBsAg at birth and were followed up for 9-15 months became negative for HBsAg after hepatitis B immunization.
CONCLUSION(S):

Assisted conception does not increase the risk for mother-to-child transmission of HBV compared with natural conception.

Copyright © 2018 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
KEYWORDS:

Hepatitis B virus; hepatitis B immunization; intracytoplasmic sperm injection; in vitro fertilization; mother-to-child transmission

PMID:
    30691633
DOI:
    10.1016/j.fertnstert.2018.10.021

StephenW

Fertil Steril。 2019年2月; 111（2）：348-356。 doi：10.1016 / j.fertnstert.2018.10.021。
与自然受孕相比，辅助受孕不会增加母婴传播乙型肝炎病毒的风险：一项前瞻性队列研究。
聂R1，王M1，廖T2，钱K1，朱G1，晋L3。
作者信息

1
    华中科技大学同济医学院同济医院生殖医学中心，中华人民共和国武汉。
2
    广东医科大学附属医院生殖医学中心，广东医科大学，中华人民共和国湛江。
3
    华中科技大学同济医学院同济医院生殖医学中心，中华人民共和国武汉。电子地址：[email protected]。

抽象
目的：

与自然受孕相比，确定辅助受孕是否会增加母婴传播乙型肝炎病毒（HBV）感染的风险。
设计：

前瞻性队列研究。
设置：

研究实验室。
耐心）：

共有305名乙型肝炎表面抗原（HBsAg-）阳性妇女共生305名儿童，其中176名出生时有辅助受孕，129名出生时患有自然受孕。
干预（S）：

没有。
主要观察指标）：

出生儿童HBsAg血清阳性率和9-15个月HBV感染率。
结果（S）：

总体而言，7.5％（23/305）的儿童出生时HBsAg阳性。出生时HBsAg阳性儿童的出生率在辅助受孕组中与自然受孕组相比无显着差异（6.3％[11/176]对比9.3％[12/129]）。多因素logistic回归分析显示，受孕方法与出生时HBsAg阳性儿童的发生率无关。所有出生时HBsAg阳性且随访9-15个月的儿童在乙型肝炎免疫接种后HBsAg阴性。
结论（S）：

与自然受孕相比，辅助受孕不会增加母婴传播HBV的风险。

版权所有©2018美国生殖医学会。由Elsevier Inc.出版。保留所有权利。
关键词：

乙型肝炎病毒;乙型肝炎免疫;卵胞浆内单精子注射;体外受精;母婴传播

结论：
    30691633
DOI：
    10.1016 / j.fertnstert.2018.10.021