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Fertil Steril. 2019 Feb;111(2):348-356. doi: 10.1016/j.fertnstert.2018.10.021.
Assisted conception does not increase the risk for mother-to-child transmission of hepatitis B virus, compared with natural conception: a prospective cohort study.
Nie R1, Wang M1, Liao T2, Qian K1, Zhu G1, Jin L3.
Author information
1
Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
2
Reproductive Medicine Center, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, People's Republic of China.
3
Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. Electronic address: [email protected].
Abstract
OBJECTIVE:
To determine whether assisted conception increases the risk for mother-to-child transmission of hepatitis B virus (HBV) infection compared with natural conception.
DESIGN:
Prospective cohort study.
SETTING:
Research laboratory.
PATIENT(S):
A total of 305 children, 176 born with assisted conception and 129 born with natural conception, were born to a total of 251 hepatitis B surface antigen- (HBsAg-) positive women.
INTERVENTION(S):
None.
MAIN OUTCOME MEASURE(S):
The seropositive rates of HBsAg in children at birth and HBV infection rates at 9-15 months of age.
RESULT(S):
Overall, 7.5% (23/305) of children were HBsAg-positive at birth. The rate of HBsAg-positive children at birth did not significantly differ between children in the assisted conception group compared with those in the natural conception group (6.3% [11/176] vs. 9.3% [12/129]). Multivariate logistic regression analysis showed that conception method is not related to the rate of HBsAg-positive children at birth. All children who were positive for HBsAg at birth and were followed up for 9-15 months became negative for HBsAg after hepatitis B immunization.
CONCLUSION(S):
Assisted conception does not increase the risk for mother-to-child transmission of HBV compared with natural conception.
Copyright © 2018 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
KEYWORDS:
Hepatitis B virus; hepatitis B immunization; intracytoplasmic sperm injection; in vitro fertilization; mother-to-child transmission
PMID:
30691633
DOI:
10.1016/j.fertnstert.2018.10.021 |
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