使用重水标记在慢性乙型肝炎感染患者中发现循环HBsAg的半衰

StephenW

Discovery of half-life of circulating HBsAg in patients with chronic hepatitis B infection using heavy water labeling
Rohit Loomba Martin Decaris Kelvin W Li Mahalakshmi Shankaran Hussein Mohammed Marcy Matthews Lisa M Richards Phirum Nguyen Emily Rizo Barbara Andrews ... Show more
Clinical Infectious Diseases, ciy1100, https://doi.org/10.1093/cid/ciy1100
Published:
24 December 2018

Abstract

In a pilot study, heavy water labeling was used to determine HBsAg turnover rates in chronic hepatitis B (CHB) patients. The mean (SD) half-life of HBsAg in blood was 6.7 (5.5) days which therefore reflects recent production in liver and supports strategies aimed at reducing HBsAg production in CHB patients.
HBV, Deuterated water, hepatitis B S antigen, half-life
Topic:

    half-life hepatitis b antigens deuterium oxide hepatitis b surface antigens hepatitis b, chronic infection hepatitis b virus hepatitis b virus measurement liver

Issue Section:
Brief Report
使用重水标记在慢性乙型肝炎感染患者中发现循环HBsAg的半衰期
Rohit Loomba Martin Decaris Kelvin W Li Mahalakshmi Shankaran Hussein Mohammed Marcy Matthews Lisa M Richards Phirum Nguyen Emily Rizo Barbara Andrews ...显示更多
临床传染病，ciy1100，https：//doi.org/10.1093/cid/ciy1100
发布时间：
2018年12月24日

抽象

在一项初步研究中，使用重水标记来确定慢性乙型肝炎（CHB）患者的HBsAg转换率。 HBsAg在血液中的平均（SD）半衰期为6.7（5.5）天，因此反映了最近在肝脏中的产生并支持旨在降低CHB患者中HBsAg产生的策略。
HBV，氘代水，乙型肝炎S抗原，半衰期
话题：

     半衰期乙型肝炎抗原氘氧化物乙型肝炎表面抗原乙型肝炎，慢性感染乙型肝炎病毒乙肝病毒测定肝脏

问题部分：
简短报告

齐欢畅

左罗

新发现哟，值得喝彩呢！