Discovery of half-life of circulating HBsAg in patients with chronic hepatitis B infection using heavy water labeling
Rohit Loomba Martin Decaris Kelvin W Li Mahalakshmi Shankaran Hussein Mohammed Marcy Matthews Lisa M Richards Phirum Nguyen Emily Rizo Barbara Andrews ... Show more
Clinical Infectious Diseases, ciy1100, https://doi.org/10.1093/cid/ciy1100
Published:
24 December 2018
Abstract
In a pilot study, heavy water labeling was used to determine HBsAg turnover rates in chronic hepatitis B (CHB) patients. The mean (SD) half-life of HBsAg in blood was 6.7 (5.5) days which therefore reflects recent production in liver and supports strategies aimed at reducing HBsAg production in CHB patients.
HBV, Deuterated water, hepatitis B S antigen, half-life
Topic:
half-life hepatitis b antigens deuterium oxide hepatitis b surface antigens hepatitis b, chronic infection hepatitis b virus hepatitis b virus measurement liver
Issue Section:
Brief Report
使用重水标记在慢性乙型肝炎感染患者中发现循环HBsAg的半衰期
Rohit Loomba Martin Decaris Kelvin W Li Mahalakshmi Shankaran Hussein Mohammed Marcy Matthews Lisa M Richards Phirum Nguyen Emily Rizo Barbara Andrews ...显示更多
临床传染病，ciy1100，https：//doi.org/10.1093/cid/ciy1100
发布时间：
2018年12月24日
