隐匿性乙型肝炎病毒感染：具有新型临床参与的老实体

StephenW

Occult Hepatitis B Virus Infection: An Old Entity With Novel Clinical Involvements
Vincenzo Malagnino Djeneba Bocar Fofana Karine Lacombe Joel Gozlan
Open Forum Infectious Diseases, Volume 5, Issue 10, 1 October 2018, ofy227, https://doi.org/10.1093/ofid/ofy227
Published:
14 September 2018

Abstract
Background

Occult hepatitis B infection (OBI) is recognized as a risk factor for cirrhosis and hepato-cellular carcinoma. However, OBI brings together a large spectrum of patients who might harbor different characteristics and prognosis.
Methods

We analyzed the databases of a university hospital in Paris to identify OBI among patients (n = 3966) concomitantly tested for hepatitis B virus (HBV) DNA and serology during a 7-year period. OBI patients were gathered into clinical entities according to their clinical records.
Results

Forty-seven OBIs were identified (1.2%). All patients had detectable anti-HBc, isolated (n = 26) or associated with anti-HBs (n = 21). The proportion of OBIs was 3.4% for patients with isolated anti-HBc and 4.2% for patients with both anti-HBc and anti-HBs. Four clinical categories of OBI patients were identified: patients with a passed HBV infection with HBs Ag clearance (group A, 23.4%); HBV-exposed patients receiving immunosuppressive therapy (group B, 29.8%); HIV/HBV-coinfected patients with therapy discontinuation (group C, 17%); HBV-exposed patients with severe liver conditions (group D, 29.8%). Significant follow-up was available for 32 patients, showing a more deleterious prognosis in group D patients, associated more with their underlying condition than the OBI status.
Conclusions

OBI is a heterogeneous condition with various clinical implications.

StephenW

隐匿性乙型肝炎病毒感染：具有新型临床参与的老实体
Vincenzo Malagnino Djeneba Bocar Fofana Karine Lacombe Joel Gozlan
Open Forum Infectious Diseases，Volume 5，Issue 10，2018 October 10，ofy227，https：//doi.org/10.1093/ofid/ofy227
发布时间：
2018年9月14日

抽象
背景

隐匿性乙型肝炎感染（OBI）被认为是肝硬化和肝细胞癌的危险因素。然而，OBI汇集了大量可能具有不同特征和预后的患者。
方法

我们分析了巴黎一所大学医院的数据库，以确定患者（n = 3966）中的OBI，同时测试了7年期间的乙型肝炎病毒（HBV）DNA和血清学。根据临床记录将OBI患者聚集到临床实体中。
结果

确定了47个OBI（1.2％）。所有患者均可检出抗-HBc，分离（n = 26）或与抗-HBs相关（n = 21）。对于分离的抗HBc患者，OBI的比例为3.4％，对于抗HBc和抗HBs的患者，OBI的比例为4.2％。确定了四种临床类型的OBI患者：HBs Ag感染HBV感染的患者（A组，23.4％）;暴露于HBV的患者接受免疫抑制治疗（B组，29.8％）;停止治疗的HIV / HBV合并感染患者（C组，17％）;接触HBV的严重肝病患者（D组，29.8％）。对32名患者进行了大量随访，显示D组患者的预后更为有害，其基础状况与OBI状态相关。
结论

OBI是一种具有各种临床意义的异质性疾病。

StephenW

https://academic.oup.com/ofid/article/5/10/ofy227/5096759