Occult Hepatitis B Virus Infection: An Old Entity With Novel Clinical Involvements
Vincenzo Malagnino Djeneba Bocar Fofana Karine Lacombe Joel Gozlan
Open Forum Infectious Diseases, Volume 5, Issue 10, 1 October 2018, ofy227, https://doi.org/10.1093/ofid/ofy227
Published:
14 September 2018
Abstract
Background
Occult hepatitis B infection (OBI) is recognized as a risk factor for cirrhosis and hepato-cellular carcinoma. However, OBI brings together a large spectrum of patients who might harbor different characteristics and prognosis.
Methods
We analyzed the databases of a university hospital in Paris to identify OBI among patients (n = 3966) concomitantly tested for hepatitis B virus (HBV) DNA and serology during a 7-year period. OBI patients were gathered into clinical entities according to their clinical records.
Results
Forty-seven OBIs were identified (1.2%). All patients had detectable anti-HBc, isolated (n = 26) or associated with anti-HBs (n = 21). The proportion of OBIs was 3.4% for patients with isolated anti-HBc and 4.2% for patients with both anti-HBc and anti-HBs. Four clinical categories of OBI patients were identified: patients with a passed HBV infection with HBs Ag clearance (group A, 23.4%); HBV-exposed patients receiving immunosuppressive therapy (group B, 29.8%); HIV/HBV-coinfected patients with therapy discontinuation (group C, 17%); HBV-exposed patients with severe liver conditions (group D, 29.8%). Significant follow-up was available for 32 patients, showing a more deleterious prognosis in group D patients, associated more with their underlying condition than the OBI status.
Conclusions
OBI is a heterogeneous condition with various clinical implications.作者: StephenW 时间: 2018-12-14 13:34
隐匿性乙型肝炎病毒感染：具有新型临床参与的老实体
Vincenzo Malagnino Djeneba Bocar Fofana Karine Lacombe Joel Gozlan
Open Forum Infectious Diseases，Volume 5，Issue 10，2018 October 10，ofy227，https：//doi.org/10.1093/ofid/ofy227
发布时间：
2018年9月14日