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标题: 隐匿性乙型肝炎病毒感染:具有新型临床参与的老实体 [打印本页]

作者: StephenW    时间: 2018-12-14 13:33     标题: 隐匿性乙型肝炎病毒感染:具有新型临床参与的老实体

Occult Hepatitis B Virus Infection: An Old Entity With Novel Clinical Involvements
Vincenzo Malagnino Djeneba Bocar Fofana Karine Lacombe Joel Gozlan
Open Forum Infectious Diseases, Volume 5, Issue 10, 1 October 2018, ofy227, https://doi.org/10.1093/ofid/ofy227
Published:
14 September 2018

Abstract
Background

Occult hepatitis B infection (OBI) is recognized as a risk factor for cirrhosis and hepato-cellular carcinoma. However, OBI brings together a large spectrum of patients who might harbor different characteristics and prognosis.
Methods

We analyzed the databases of a university hospital in Paris to identify OBI among patients (n = 3966) concomitantly tested for hepatitis B virus (HBV) DNA and serology during a 7-year period. OBI patients were gathered into clinical entities according to their clinical records.
Results

Forty-seven OBIs were identified (1.2%). All patients had detectable anti-HBc, isolated (n = 26) or associated with anti-HBs (n = 21). The proportion of OBIs was 3.4% for patients with isolated anti-HBc and 4.2% for patients with both anti-HBc and anti-HBs. Four clinical categories of OBI patients were identified: patients with a passed HBV infection with HBs Ag clearance (group A, 23.4%); HBV-exposed patients receiving immunosuppressive therapy (group B, 29.8%); HIV/HBV-coinfected patients with therapy discontinuation (group C, 17%); HBV-exposed patients with severe liver conditions (group D, 29.8%). Significant follow-up was available for 32 patients, showing a more deleterious prognosis in group D patients, associated more with their underlying condition than the OBI status.
Conclusions

OBI is a heterogeneous condition with various clinical implications.
作者: StephenW    时间: 2018-12-14 13:34

隐匿性乙型肝炎病毒感染:具有新型临床参与的老实体
Vincenzo Malagnino Djeneba Bocar Fofana Karine Lacombe Joel Gozlan
Open Forum Infectious Diseases,Volume 5,Issue 10,2018 October 10,ofy227,https://doi.org/10.1093/ofid/ofy227
发布时间:
2018年9月14日

抽象
背景

隐匿性乙型肝炎感染(OBI)被认为是肝硬化和肝细胞癌的危险因素。然而,OBI汇集了大量可能具有不同特征和预后的患者。
方法

我们分析了巴黎一所大学医院的数据库,以确定患者(n = 3966)中的OBI,同时测试了7年期间的乙型肝炎病毒(HBV)DNA和血清学。根据临床记录将OBI患者聚集到临床实体中。
结果

确定了47个OBI(1.2%)。所有患者均可检出抗-HBc,分离(n = 26)或与抗-HBs相关(n = 21)。对于分离的抗HBc患者,OBI的比例为3.4%,对于抗HBc和抗HBs的患者,OBI的比例为4.2%。确定了四种临床类型的OBI患者:HBs Ag感染HBV感染的患者(A组,23.4%);暴露于HBV的患者接受免疫抑制治疗(B组,29.8%);停止治疗的HIV / HBV合并感染患者(C组,17%);接触HBV的严重肝病患者(D组,29.8%)。对32名患者进行了大量随访,显示D组患者的预后更为有害,其基础状况与OBI状态相关。
结论

OBI是一种具有各种临床意义的异质性疾病。
作者: StephenW    时间: 2018-12-14 13:34

https://academic.oup.com/ofid/article/5/10/ofy227/5096759




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