慢性乙型肝炎病毒感染和血脂异常风险：一项队列研究。

StephenW

J Viral Hepat. 2018 Sep 29. doi: 10.1111/jvh.13014. [Epub ahead of print]
Chronic Hepatitis B Virus Infection and Risk of Dyslipidemia: A Cohort Study.
Joo EJ1, Chang Y2,3,4, Yeom JS5, Cho YK6, Ryu S3,4,5.
Author information

1
    Division of Infectious Diseases, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
2
    Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul.
3
    Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine.
4
    Department of Clinical Research Design& Evaluation, SAIHST, Sungkyunkwan University, Seoul, South Korea.
5
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
6
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.

Abstract

HBV infection has been associated with a decreased prevalence of dyslipidemia in cross-sectional studies, but cohort studies are limited. We investigated the longitudinal effects of chronic HBV infection on the development of dyslipidemia. We performed a cohort study of 62,287 non-cirrhotic adult men and women free of dyslipidemia who underwent serologic testing for hepatitis B surface antigen (HBsAg) and were followed annually or biennially for an average of 4.46 years. A parametric Cox model was used to estimate the adjusted hazard ratio with 95% confidence interval (CI) for incident dyslipidemia according to HBsAg seropositivity status. We identified 12,331 incident cases of hypercholesterolemia during 278,004.4 person-years of follow-up (incident rate 44.3 per 1,000 person-years). In models adjusted for age, sex, body mass index, year of screening exam, smoking status, alcohol intake, regular exercise, and education level, the adjusted hazard ratioS (95% CIs) for incident hypercholesterolemia, high LDL cholesterolemia, hypertriglyceridemia, high non-HDL cholesterolemia, and low HDL-cholesterolemia comparing HBsAg-positive to HBsAg-negative participants was 0.71 (0.64-0.79), 0.83 (0.78-0.89), 0.61 (0.54-0.70), 0.69 (0.63-0.75), and 1.10 (0.98-1.24), respectively. An inverse association between HBsAg positivity and incident high apolipoprotein B were also identified, with a corresponding a hazard ratio of 0.63 (0.55-0.72). In a large cohort of apparently healthy Korean adults, HBsAg seropositivity was associated with lower risk of development of dyslipidemia, suggesting a role of HBV infection in lipid metabolism. This article is protected by copyright. All rights reserved.
KEYWORDS:

Cohort Study; Dyslipidemia; Hepatitis B Virus; Incidence; Risk

PMID:
    30267602
DOI:
    10.1111/jvh.13014

StephenW

J病毒肝病。 2018年9月29日.doi：10.1111 / jvh.13014。 [提前打印]
慢性乙型肝炎病毒感染和血脂异常风险：一项队列研究。
Joo EJ1，Chang Y2,3,4，Yeom JS5，Cho YK6，Ryu S3,4,5。
作者信息

1
    成均馆大学医学院Kangbuk三星医院内科，传染病科。
2
    首尔成均馆大学医学院Kangbuk三星医院职业与环境医学系。
3
    中央医科大学医学院，成都三星医院全医疗中心队列研究中心。
4
    韩国首尔成均馆大学SAIHST临床研究设计与评估系。
五
    韩国延世大学医学院内科，韩国首尔。
6
    成均馆大学医学院Kangbuk三星医院内科，消化内科和肝病科。

抽象

在横断面研究中，HBV感染与血脂异常的患病率降低有关，但队列研究有限。我们调查了慢性HBV感染对血脂异常发展的纵向影响。我们对62,287例无血脂异常的非肝硬化成人男性和女性进行了队列研究，这些男性和女性接受了乙型肝炎表面抗原（HBsAg）的血清学检测，并且每年或每两年进行一次平均4。46年的随访。根据HBsAg血清阳性状态，使用参数Cox模型估计调整后的风险比，其中95％置信区间（CI）用于发生血脂异常。我们在278,004.4人年的随访期间发现了12,331例高胆固醇血症事件（事件发生率44.3 / 1000人年）。在根据年龄，性别，体重指数，筛查年份，吸烟状况，酒精摄入量，经常锻炼和教育水平调整的模型中，事件高胆固醇血症，高LDL胆固醇血症，高甘油三酯血症，高的调整风险比率S（95％CIs）非HDL胆固醇血症和HBsAg阳性与HBsAg阴性参与者相比的低HDL-胆固醇血症为0.71（0.64-0.79），0.83（0.78-0.89），0.61（0.54-0.70），0.69（0.63-0.75）和1.10 （0.98-1.24），分别。还鉴定了HBsAg阳性与入射高载脂蛋白B之间的反向关联，相应的风险比为0.63（0.55-0.72）。在一大群表面健康的韩国成年人中，HBsAg血清阳性与血脂异常的发生风险降低相关，提示HBV感染在脂质代谢中的作用。本文受版权保护。版权所有。
关键词：

队列研究;血脂异常;乙型肝炎病毒;发病率;风险

结论：
    30267602
DOI：
    10.1111 / jvh.13014