J Viral Hepat. 2018 Sep 29. doi: 10.1111/jvh.13014. [Epub ahead of print]
Chronic Hepatitis B Virus Infection and Risk of Dyslipidemia: A Cohort Study.
Joo EJ1, Chang Y2,3,4, Yeom JS5, Cho YK6, Ryu S3,4,5.
Author information
1
Division of Infectious Diseases, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
2
Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul.
3
Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine.
4
Department of Clinical Research Design& Evaluation, SAIHST, Sungkyunkwan University, Seoul, South Korea.
5
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
6
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine.
Abstract
HBV infection has been associated with a decreased prevalence of dyslipidemia in cross-sectional studies, but cohort studies are limited. We investigated the longitudinal effects of chronic HBV infection on the development of dyslipidemia. We performed a cohort study of 62,287 non-cirrhotic adult men and women free of dyslipidemia who underwent serologic testing for hepatitis B surface antigen (HBsAg) and were followed annually or biennially for an average of 4.46 years. A parametric Cox model was used to estimate the adjusted hazard ratio with 95% confidence interval (CI) for incident dyslipidemia according to HBsAg seropositivity status. We identified 12,331 incident cases of hypercholesterolemia during 278,004.4 person-years of follow-up (incident rate 44.3 per 1,000 person-years). In models adjusted for age, sex, body mass index, year of screening exam, smoking status, alcohol intake, regular exercise, and education level, the adjusted hazard ratioS (95% CIs) for incident hypercholesterolemia, high LDL cholesterolemia, hypertriglyceridemia, high non-HDL cholesterolemia, and low HDL-cholesterolemia comparing HBsAg-positive to HBsAg-negative participants was 0.71 (0.64-0.79), 0.83 (0.78-0.89), 0.61 (0.54-0.70), 0.69 (0.63-0.75), and 1.10 (0.98-1.24), respectively. An inverse association between HBsAg positivity and incident high apolipoprotein B were also identified, with a corresponding a hazard ratio of 0.63 (0.55-0.72). In a large cohort of apparently healthy Korean adults, HBsAg seropositivity was associated with lower risk of development of dyslipidemia, suggesting a role of HBV infection in lipid metabolism. This article is protected by copyright. All rights reserved.
KEYWORDS:
Cohort Study; Dyslipidemia; Hepatitis B Virus; Incidence; Risk