母亲的不良后果与乙型肝炎病毒感染群体的后代疾病进展和

StephenW

Medicine (Baltimore). 2018 Sep;97(38):e12266. doi: 10.1097/MD.0000000000012266.
The association of adverse outcomes in the mother with disease progression in offspring in families with clusters of hepatitis B virus infection and unfavorable prognoses in Northwest China.
Yang Y1, Jin L1, Tian Z1, Guo D1, Yao N1, Li Q2, Jiang Z3, Yang D4, Tang X5, Li H6, He Y1, Liu J1, Chen T1, Zhao Y1.
Author information

1
    Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University.
2
    Xian Center for Disease Control and Prevention, Xi'an.
3
    Department of Infectious Diseases, Ankang City Central Hospital, Ankang, Shaanxi.
4
    Department of Infectious Diseases, Xinxiang Medical University, Xinxiang, Henan.
5
    Department of Infectious Diseases, Hanzhong Central Hospital, Hanzhong.
6
    Department of Infectious Diseases, Weinan Central Hospital, Weinan, Shaanxi, People's Republic of China.

Abstract

To investigate the transmission routes of hepatitis B virus (HBV) in families with clusters of infection and unfavorable prognoses and to analyze the prevalence of liver cirrhosis (LC) or hepatocellular carcinoma (HCC) in the offspring of these families.Families with clusters of HBV infection and unfavorable prognoses were enrolled in the study, and general information and serum samples were collected. The prevalence of LC or HCC was compared in offspring of different genders whose parents were diagnosed with LC or HCC.This analysis comprised 102 probands with 51 siblings, 15 parents, 284 children, and 74 spouses. Interestingly, 88.2% of the siblings and 76.8% of the children of these probands were positive for hepatitis B surface antigen (HBsAg), compared with only 9.5% of the spouses (P < .001). There were 266 nuclear families from 102 clustering families. The prevalence of LC or HCC in sons (44.8%) was higher than that in daughters (8.2%; P < .05) in families with mothers with LC or HCC, but there was no difference in families with fathers with LC or HCC. Moreover, the prevalence of LC or HCC in sons from families with mothers with LC or HCC (44.8%) was higher than in the families with fathers with LC or HCC (21.0%, P = .016).The development of LC or HCC in offspring showed a greater relationship with the adverse outcomes induced by HBV infection in the mother compared with the father, and the prevalence of LC or HCC was much higher in male offspring.

PMID:
    30235671
DOI:
    10.1097/MD.0000000000012266

StephenW

医学（巴尔的摩）。 2018年9月; 97（38）：e12266。 doi：10.1097 / MD.0000000000012266。
母亲的不良后果与乙型肝炎病毒感染群体的后代疾病进展和中国西北地区不利预后的关系。
杨艳1，金丽1，田子1，郭D1，姚娜1，李群2，江Z3，杨D4，唐X5，李H6，何Y1，刘J1，陈T1，赵Y1。
作者信息

1
    西安交通大学第一附属医院感染科
2
    西安市西安市疾病预防控制中心。
3
    陕西省安康市安康市中心医院感染科
4
    新乡医科大学传染病科，河南新乡
五
    汉中市汉中市中心医院感染科
6
    中华人民共和国陕西省渭南市渭南市中心医院感染科。

抽象

与感染的集群和不利预后调查乙型肝炎病毒的在家庭中传输途径（HBV）和与HBV的簇分析肝硬化（LC）或肝细胞癌（HCC）的患病率在这些families.Families的后代在该研究中纳入了感染和不利的预后，并收集了一般信息和血清样品。在父母被诊断患有LC或HCC的不同性别的后代中比较LC或HCC的患病率。该分析包括102名先证者，51名兄弟姐妹，15名父母，284名儿童和74名配偶。有趣的是，88.2％的兄弟姐妹和76.8％的这些先证者的儿童乙型肝炎表面抗原（HBsAg）阳性，而配偶只有9.5％（P <.001）。来自102个聚类家庭的266个核心家庭。在患有LC或HCC的母亲的家庭中，儿童中LC或HCC的患病率（44.8％）高于女儿（8.2％; P <.05），但患有LC或HCC的父亲的家庭没有差异。此外，患有LC或HCC的母亲（44.8％）的儿子中LC或HCC的患病率高于患有LC或HCC的父母的家庭（21.0％，P = .016）.LC或HCC的发展与父亲相比，后代与母亲HBV感染引起的不良后果显示出更大的关系，男性后代的LC或HCC患病率更高。

结论：
    30235671
DOI：
    10.1097 / MD.0000000000012266