Medicine (Baltimore). 2018 Sep;97(38):e12266. doi: 10.1097/MD.0000000000012266.
The association of adverse outcomes in the mother with disease progression in offspring in families with clusters of hepatitis B virus infection and unfavorable prognoses in Northwest China.
Yang Y1, Jin L1, Tian Z1, Guo D1, Yao N1, Li Q2, Jiang Z3, Yang D4, Tang X5, Li H6, He Y1, Liu J1, Chen T1, Zhao Y1.
Author information
1
Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University.
2
Xian Center for Disease Control and Prevention, Xi'an.
3
Department of Infectious Diseases, Ankang City Central Hospital, Ankang, Shaanxi.
4
Department of Infectious Diseases, Xinxiang Medical University, Xinxiang, Henan.
5
Department of Infectious Diseases, Hanzhong Central Hospital, Hanzhong.
6
Department of Infectious Diseases, Weinan Central Hospital, Weinan, Shaanxi, People's Republic of China.
Abstract
To investigate the transmission routes of hepatitis B virus (HBV) in families with clusters of infection and unfavorable prognoses and to analyze the prevalence of liver cirrhosis (LC) or hepatocellular carcinoma (HCC) in the offspring of these families.Families with clusters of HBV infection and unfavorable prognoses were enrolled in the study, and general information and serum samples were collected. The prevalence of LC or HCC was compared in offspring of different genders whose parents were diagnosed with LC or HCC.This analysis comprised 102 probands with 51 siblings, 15 parents, 284 children, and 74 spouses. Interestingly, 88.2% of the siblings and 76.8% of the children of these probands were positive for hepatitis B surface antigen (HBsAg), compared with only 9.5% of the spouses (P < .001). There were 266 nuclear families from 102 clustering families. The prevalence of LC or HCC in sons (44.8%) was higher than that in daughters (8.2%; P < .05) in families with mothers with LC or HCC, but there was no difference in families with fathers with LC or HCC. Moreover, the prevalence of LC or HCC in sons from families with mothers with LC or HCC (44.8%) was higher than in the families with fathers with LC or HCC (21.0%, P = .016).The development of LC or HCC in offspring showed a greater relationship with the adverse outcomes induced by HBV infection in the mother compared with the father, and the prevalence of LC or HCC was much higher in male offspring.