健康成人的标准和加速乙型肝炎病毒疫苗接种计划的短期免

StephenW

Biosci Rep. 2018 Sep 10. pii: BSR20180846. doi: 10.1042/BSR20180846. [Epub ahead of print]
Short-term immunogenicity of standard and accelerated hepatitis B virus vaccination schedules in healthy adults: a comparative field study in China.
Zhang X1, Wang J2, Chen X1, Yu M3, Yu S1, Sun Y4, Duan J5, Sun H5, Yuan P6.
Author information

1
    Department of Epidemiology and Statistics, West China School of Public Health, Sichuan University, Chengdu, China.
2
    Center of Infectious Disease, West China Hospital, Sichuan University, Chengdu, China.
3
    Department of Epidemiology and Statistics, West China School of Public Health, Sichuan University, Chengu, China.
4
    Department of Epidemiology and Statistics, West China School of Public Health, Sichuan University, Chendu, China.
5
    Center for Disease Control and Prevention of Mianyang, Mianyang, China.
6
    Department of Epidemiology and Statistics, West China School of Public Health, Sichuan University, Chengu, China [email protected].

Abstract

World Health Organization recommend HBV immunization at 0, 1, and 6 months. However, studies have suggested that shortening the interval between the first and last HBV immunization can improve completion rates. Less clear is whether accelerated immunization is as immunogenic as standard immunization. Thus, this study aimed to compare the short-term immunogenicity of yeast-derived hepatitis B vaccine in healthy adults immunized on an accelerated or standard schedule. Between June 2013 and March 2014, individuals from Jinfeng and Longmen, China were randomly assigned to receive the vaccine on an accelerated schedule (at 0, 1, and 2 months; n = 201) or a standard schedule (at 0, 1, and 6 months; n = 206). Subjects filled out a questionnaire asking about demographic and other health data, and they underwent physical examination. Blood was assayed for HBsAg and HBV surface antibody (HBsAb) at 1-2 months after the three-dose schedule. Multivariate binary logistic regression was used to determine whether the rate of anti-HBs seroconversion differed with immunization schedule. Covariance analysis was used to compare geometric mean HBsAb concentration between the two schedules. The anti-HBs seroconversion rate was 84.6% in the accelerated group and 90.3% in the standard group. After controlling for several potential confounders, the accelerated schedule was associated with significantly lower anti-HBs seroconversion rate (OR 0.560, 95%CI 0.318-0.988). Similarly, the accelerated schedule was associated with significantly lower geometric mean HBsAb concentration. These results suggest that the standard schedule is more likely to lead to anti-HBs seroconversion and higher HBsAb levels in adults.
KEYWORDS:

Hepatitis B virus; accelerated schedule; hepatitis B vaccine; immunization program; standard schedule

PMID:
    30201691
DOI:
    10.1042/BSR20180846

StephenW

Biosci Rep.2018 9月10日.pii：BSR20180846。 doi：10.1042 / BSR20180846。 [提前打印]
健康成人的标准和加速乙型肝炎病毒疫苗接种计划的短期免疫原性：中国的比较实地研究。
Zhang X1，Wang J2，Chen X1，Yu M3，Yu S1，Sun Y4，Duan J5，Sun H5，Yuan P6。
作者信息

1
    四川大学华西公共卫生学院流行病学与统计学系，中国成都。
2
    四川大学华西医院传染病研究中心，成都
3
    四川大学华西公共卫生学院流行病学与统计学系，中国。
4
    四川大学华西公共卫生学院流行病与统计学系，中国成都。
五
    绵阳市绵阳市疾病预防控制中心。
6
    四川大学华西公共卫生学院流行病学与统计学系，中国平谷，yuanping1117 @ 126.com。

抽象

世界卫生组织建议在0,1和6个月进行HBV免疫。然而，研究表明，缩短第一次和最后一次HBV免疫接种之间的间隔可以提高完成率。不太清楚的是加速免疫是否与标准免疫一样具有免疫原性。因此，本研究旨在比较酵母来源的乙型肝炎疫苗在加速或标准时间表免疫的健康成人中的短期免疫原性。 2013年6月至2014年3月期间，来自中国金丰和龙门的个体被随机分配接受疫苗加速（0,1和2个月; n = 201）或标准时间表（0,1和6个月; n = 206）。受试者填写了一份询问人口统计和其他健康数据的调查问卷，并对他们进行了体检。在三剂量方案后1-2个月测定血液中的HBsAg和HBV表面抗体（HBsAb）。多变量二元logistic回归用于确定抗HBs血清转换率是否与免疫计划不同。协方差分析用于比较两个时间表之间的几何平均HBsAb浓度。加速组的抗HBs血清转换率为84.6％，标准组为90.3％。在控制了几种潜在的混杂因素之后，加速方案与显着降低的抗HBs血清转换率相关（OR 0.560,95％CI 0.318-0.988）。同样，加速时间表与几何平均HBsAb浓度显着降低相关。这些结果表明，标准时间表更有可能导致成人抗HBs血清转换和更高的HBsAb水平。
关键词：

乙型肝炎病毒;加速进度;乙肝疫苗;免疫计划;标准时间表

结论：
    30201691
DOI：
    10.1042 / BSR20180846