Biosci Rep. 2018 Sep 10. pii: BSR20180846. doi: 10.1042/BSR20180846. [Epub ahead of print]
Short-term immunogenicity of standard and accelerated hepatitis B virus vaccination schedules in healthy adults: a comparative field study in China.
Zhang X1, Wang J2, Chen X1, Yu M3, Yu S1, Sun Y4, Duan J5, Sun H5, Yuan P6.
Author information
1
Department of Epidemiology and Statistics, West China School of Public Health, Sichuan University, Chengdu, China.
2
Center of Infectious Disease, West China Hospital, Sichuan University, Chengdu, China.
3
Department of Epidemiology and Statistics, West China School of Public Health, Sichuan University, Chengu, China.
4
Department of Epidemiology and Statistics, West China School of Public Health, Sichuan University, Chendu, China.
5
Center for Disease Control and Prevention of Mianyang, Mianyang, China.
6
Department of Epidemiology and Statistics, West China School of Public Health, Sichuan University, Chengu, China [email protected].
Abstract
World Health Organization recommend HBV immunization at 0, 1, and 6 months. However, studies have suggested that shortening the interval between the first and last HBV immunization can improve completion rates. Less clear is whether accelerated immunization is as immunogenic as standard immunization. Thus, this study aimed to compare the short-term immunogenicity of yeast-derived hepatitis B vaccine in healthy adults immunized on an accelerated or standard schedule. Between June 2013 and March 2014, individuals from Jinfeng and Longmen, China were randomly assigned to receive the vaccine on an accelerated schedule (at 0, 1, and 2 months; n = 201) or a standard schedule (at 0, 1, and 6 months; n = 206). Subjects filled out a questionnaire asking about demographic and other health data, and they underwent physical examination. Blood was assayed for HBsAg and HBV surface antibody (HBsAb) at 1-2 months after the three-dose schedule. Multivariate binary logistic regression was used to determine whether the rate of anti-HBs seroconversion differed with immunization schedule. Covariance analysis was used to compare geometric mean HBsAb concentration between the two schedules. The anti-HBs seroconversion rate was 84.6% in the accelerated group and 90.3% in the standard group. After controlling for several potential confounders, the accelerated schedule was associated with significantly lower anti-HBs seroconversion rate (OR 0.560, 95%CI 0.318-0.988). Similarly, the accelerated schedule was associated with significantly lower geometric mean HBsAb concentration. These results suggest that the standard schedule is more likely to lead to anti-HBs seroconversion and higher HBsAb levels in adults.
KEYWORDS:
Hepatitis B virus; accelerated schedule; hepatitis B vaccine; immunization program; standard schedule