老年肝细胞癌患者的肝切除术：对17,000多名患者进行了系统

StephenW

Hepatic resection for elderly patients with hepatocellular carcinoma: a systematic review of more than 17,000 patients
Ling-Yun Zhao, Rong-Rui Huo, Xiao Xiang, Guido Torzilli, Ming-Hua Zheng, Tian Yang, show all
Received 06 Mar 2018, Accepted 24 Aug 2018, Accepted author version posted online: 26 Aug 2018

    Download citation https://doi.org/10.1080/17474124.2018.1517045

Accepted author version
Abstract

Aims: The present systematic review investigates postoperative morbidity, hospital mortality, median survival time, overall and disease-free survival in elderly patients with hepatocellular carcinoma (HCC) undergoing hepatic resection.

Background: With the aging population and increasing incidence of hepatic malignancies in elderly patients, establishing the safety and efficacy of hepatic resectionfor elderly patients with HCC is crucial.

Methods: Some databaseswere systematically searched for prospective or retrospective studies to reveal the safety and efficacy ofhepatic resection for elderly patientswith primary HCC.

Result: Fifty studies involving 4,169 elderly patients and 13,158 young patientswith HCC were included into analyses. Elderly group patients had similar rate of median postoperative morbidity (28.2% vs. 29.6%) but higher mortality (3.0% vs. 1.2%) with young group patients. Moreover, elderly group patients had slightly lower median survival time (55 vs. 58 months), 5-years overall survival (51% vs. 56%) and 5-years disease-free survival (27% vs. 28%) than young group patients. There was an upward trend in 5-years overall and disease-free survivalin either elderly or young group.

Conclusion: Though old age may increase the risk of hospital mortality for patients with HCC after hepatic resection, elderly patients can obtain acceptable long-term prognoses from hepatic resection.
Keywords: elderly patients, hepatic resection, hepatocellular carcinoma, mortality, overall survival

StephenW

老年肝细胞癌患者的肝切除术：对17,000多名患者进行了系统评价
赵玲云，霍荣瑞，肖翔，Guido Torzilli，郑明华，田阳，全部展示
2018年3月6日收到，2018年8月24日接受，接受作者版本在线发布：2018年8月26日

    下载引文https://doi.org/10.1080/17474124.2018.1517045

接受的作者版本
抽象

目的：本系统评价研究老年肝细胞癌（HCC）肝切除术后患者的术后发病率，住院死亡率，中位生存时间，总体和无病生存率。

背景：随着人口老龄化和老年患者肝脏恶性肿瘤发病率的增加，确定老年肝癌患者肝切除术的安全性和有效性至关重要。

方法：系统地搜索一些数据库进行前瞻性或回顾性研究，以揭示老年原发性肝癌患者肝切除术的安全性和有效性。

结果：纳入了50项研究，涉及4,169名老年患者和13,158名年轻HCC患者。老年组患者术后中位发病率中位数相似（28.2％对29.6％），但年轻组患者死亡率较高（3.0％对1.2％）。此外，老年组患者的中位生存时间（55对58个月），5年总生存率（51％对56％）和5年无病生存率（27％对28％）略低于年轻人小组患者。无论是老年人还是年轻人，总体上5年无病生存率呈上升趋势。

结论：老年患者虽然老年可能增加肝切除术后HCC患者的住院死亡风险，但老年患者可以从肝切除术中获得可接受的长期预后。
关键词：老年患者，肝切除术，肝细胞癌，死亡率，总生存期