Hepatic resection for elderly patients with hepatocellular carcinoma: a systematic review of more than 17,000 patients
Ling-Yun Zhao, Rong-Rui Huo, Xiao Xiang, Guido Torzilli, Ming-Hua Zheng, Tian Yang, show all
Received 06 Mar 2018, Accepted 24 Aug 2018, Accepted author version posted online: 26 Aug 2018
Aims: The present systematic review investigates postoperative morbidity, hospital mortality, median survival time, overall and disease-free survival in elderly patients with hepatocellular carcinoma (HCC) undergoing hepatic resection.
Background: With the aging population and increasing incidence of hepatic malignancies in elderly patients, establishing the safety and efficacy of hepatic resectionfor elderly patients with HCC is crucial.
Methods: Some databaseswere systematically searched for prospective or retrospective studies to reveal the safety and efficacy ofhepatic resection for elderly patientswith primary HCC.
Result: Fifty studies involving 4,169 elderly patients and 13,158 young patientswith HCC were included into analyses. Elderly group patients had similar rate of median postoperative morbidity (28.2% vs. 29.6%) but higher mortality (3.0% vs. 1.2%) with young group patients. Moreover, elderly group patients had slightly lower median survival time (55 vs. 58 months), 5-years overall survival (51% vs. 56%) and 5-years disease-free survival (27% vs. 28%) than young group patients. There was an upward trend in 5-years overall and disease-free survivalin either elderly or young group.
Conclusion: Though old age may increase the risk of hospital mortality for patients with HCC after hepatic resection, elderly patients can obtain acceptable long-term prognoses from hepatic resection.
Keywords: elderly patients, hepatic resection, hepatocellular carcinoma, mortality, overall survival 作者: StephenW 时间: 2018-8-29 09:40