箭头2018欧肝会数据 pdf

newchinabok

http://ir.arrowheadpharma.com/st ... 9-942e-cb5ed100c2b2

newchinabok

http://ir.arrowheadpharma.com/st ... a-87a0-f82125d0196b

齐欢畅

不错不错

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• 1/5 HBeAg neg showed HBsAg seroclearance event off ARC-520

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In Conclusion…
ARO-HBV is a subcutaneously administered RNAi therapeutic targeting all HBV transcripts produced by both cccDNA and integrated HBV
• One RNAi trigger in the S region and another in the X region
• S and X triggers each contribute to knockdown of HBeAg, the combined effect being greater
than that of either trigger alone
• Full activity of S trigger expected on HBV integration-derived HBsAg lacking X trigger site
• Durable reduction of HBV RNA, HBsAg, HBeAg and serum HBV DNA from single dose
• Repeat dosing produces deep reduction of HBsAg, HBeAg and serum HBV DNA
• ARO-HBV is synergistic with entecavir and expected to be synergistic with other direct acting HBV therapeutics
• Doses up to 300 mg/kg given weekly x 3 well tolerated in rats and cynomologus monkeys

hchu

单剂量可连续降低HBV RNA、HBsAg、HBeAg和血清HBV DNA。重复剂量可使HBsAg、HBeAg和血清HBV DNA深度降低。

newchinabok

hchu 发表于 2018-4-14 20:41
单剂量可连续降低HBV RNA、HBsAg、HBeAg和血清HBV DNA。重复剂量可使HBsAg、HBeAg和血清HBV DNA深度降低。 ...

这个强度对一，二百单位hbsag患者够了，加点免疫剂有可能治愈。对500以上单位hbsag还不够

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newchinabok 发表于 2018-4-14 20:46
这个强度对一，二百单位hbsag患者够了，加点免疫剂有可能治愈。对500以上单位hbsag还不够 ...

免疫激活

newchinabok

齐欢畅 发表于 2018-4-14 20:55
免疫激活

500单位以上，怕激活免疫也难呀！

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深度耐受的人，其实也没啥事。