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回复 newchinabok 的帖子
聚合物技术每年都有一次年会, NAP 是一种Oligonucleotide形式.
TIDES: Oligonucleotide and Peptide Therapeutics
May 7-10, 2018
Hynes Convention Center,
Boston, MA
https://lifesciences.knect365.com/tides/
rep聚合物技术权威刊物上有论文吗?
Nucleic acid polymer REP 2139 and nucleos(t)ide analogues act synergistically against chronic hepadnaviral infection in vivo.
Quinet J, Jamard C, Burtin M, Lemasson M, Guerret S, Sureau C, Vaillant A, Cova L. Hepatology 2017 epub Dec 18 2017.
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Nucleic acid polymers are active against Hepatitis Delta Virus infection in vitro.
Beilstein F, Blanchet M, Vaillant A, Sureau C. Journal of Virology 2017 epub Dec 6 2017.
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Activity of nucleic acid polymers in rodent models of HBV infection.
Schöneweis K, Motter N, Roppert PL, Lu M, Wang B, Roehl I, Glebe D, Yang D, Morrey JD, Roggendorf M, Vaillant A. Antiviral Research 2017 epub Nov 8, 2017.
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Safety and efficacy of REP 2139 and pegylated interferon alfa-2a for treatment-naive patients with chronic hepatitis B virus and hepatitis D virus co-infection (REP 301 and REP 301-LTF): a non-randomised, open-label, phase 2 trial
Bazinet M, Pântea V, Cebotarescu V, Cojuhari L, Jimbei P, Albrecht J, Schmid P, Le Gal F, Gordien E, Krawczyk A, Mijočević H, Karimzadeh H, Roggendorf M, Vaillant A. The Lancet Gastroenterology & Hepatology 2017 epub Sept 27, 2017.
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REP 301 study protocol
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Inhibition of hepatitis B viral entry by nucleic acid polymers in HepaRG cells and primary human hepatocytes
Guillot C, Martel N, Berby F, Bordes I, Hantz O, Blanchet M, Sureau C, Vaillant A, Chemin I. PLOS ONE 2017 12: e0179697.
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Nucleic Acid Polymers with Accelerated Plasma and Tissue Clearance for Chronic Hepatitis B Therapy.
Roehl I, Seiffert S, Brikh C, Quinet Q, Jamard C, Dorfler N, Lockridge JA, Cova L, Andrew Vaillant A. Mol Ther Nuc Acids. 2017 8: 1-12.
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Nucleic acid-based polymers effective against hepatitis B Virus infection in patients don’t harbor immunostimulatory properties in primary isolated liver cells.
Real CI, Werner M, Paul A, Gerken G, Schlaak JF, Vaillant A, Broering B, Sci. Reports. 2017 7: 43838.
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Nucleic acid polymers: Broad spectrum antiviral activity, antiviral mechanisms and optimization for the treatment of hepatitis B and hepatitis D infection. Vaillant A. Antiviral Research 2016 133: 32-40.
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Safety and Efficacy of Nucleic Acid Polymers in Monotherapy and Combined with Immunotherapy in Treatment-Naive Bangladeshi Patients with HBeAg+ Chronic Hepatitis B Infection. Al-Mahtab M, Bazinet M, Vaillant A. PLOS ONE 2016 11: e0156667.
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Therapeutic Antiviral Effect of the Nucleic Acid Polymer REP 2055 against Persistent Duck Hepatitis B Virus Infection. Noordeen F, Scougall CA, Grosse A, Qiao Q, Ajilian BB, Reache-Miller G, Finnie J, Werner M, Broering R, Schlaak J, Vaillant A, Jilbert AR. PLOS ONE 10: e0140909.
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Nucleic acid polymers prevent the establishment of duck hepatitis B virus infection in vivo. Noordeen F, Vaillant A, Jilbert AR. Antimicrob Agents Chemother. 2013 57:5299-5306.
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Nucleic acid polymers inhibit duck hepatitis B virus infection in vitro. Noordeen F, Vaillant A, Jilbert AR. Antimicrob Agents Chemother. 2013 57:5291-5298.
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Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infection. Cardin RD, Bravo FJ, Sewell AP, Cummins J, Flamand L, Juteau JM, Bernstein DI, Vaillant A. Virology Journal 2009, 6:214.
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Amphipathic DNA polymers inhibit hepatitis C virus infection by blocking viral entry. Matsumura T, Hu Z, Kato T, Dreux M, Zhang YY, Imamura M, Hiraga N, Juteau JM, Cosset FL, Chayama K, Vaillant A, Liang TJ. Gastroenterology. 2009 Aug;137(2):673-81.
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Amphipathic DNA polymers exhibit antiherpetic activity in vitro and in vivo. Bernstein DI, Goyette N, Cardin R, Kern ER, Boivin G, Ireland J, Juteau JM, Vaillant A. Antimicrob Agents Chemother. 2008 Aug;52(8):2727-33.
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Amphipathic DNA polymers are candidate vaginal microbicides and block herpes simplex virus binding, entry and viral gene expression. Guzman EM, Cheshenko N, Shende V, Keller MJ, Goyette N, Juteau JM, Boivin G, Vaillant A, Herold BC. Antivir Ther. 2007;12(8):1147-56. Erratum in: Antivir Ther. 2008;13(2):335.
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Inhibition of cellular entry of lymphocytic choriomeningitis virus by amphipathic DNA polymers. Lee AM, Rojek JM, Gundersen A, Ströher U, Juteau JM, Vaillant A, Kunz S. Virology. 2008 Mar 1;372(1):107-17.
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Phosphorothioate oligonucleotides inhibit human immunodeficiency virus type 1 fusion by blocking gp41 core formation. Vaillant A, Juteau JM, Lu H, Liu S, Lackman-Smith C, Ptak R, Jiang S. Antimicrob Agents Chemother. 2006 Apr;50(4):1393-401.
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能治hbv的理论依据是什么?临床证据, 降低血清HBsAg加免疫疗法导致功能性治愈.
当然只代表我个人的观点, 与你的完全相反. |
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